Manuscripts on Renal Disease

Xie S-K, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta SK, Mohan, C. (2001) Genetic contributions of SWR towards lupus nephritis. J Immunol 167:7150-7156.

Xie C, Liang E, and Mohan C. (2003) Use of a novel elution regime reveals the dominance of cross-reactive anti-dsDNA autoantibodies in lupus kidneys. Arthritis Rheum 48:2343-2352.

Xie C, Zhou JX, and Mohan C. (2003) Enhanced susceptibility to nephritis in the lupus facilitating NZW strain. Arthritis Rheum 48:1080-1092.

Limaye N, and Mohan C. 2004. Pathogenicity of anti-DNA and anti-glomerular antibodies: weighing the evidence. Drug Discovery Today: Disease Models 1(4):395-403.

Xie C, Ruchi Sharma R, Wang H, Zhou XJ, and C Mohan. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172: 5047 – 5055.

Fu Y, Xie C, Yan M, Li Q, Lu C, and C Mohan. 2005. LPS-induced mesangial transcriptome – evaluating the role of interferon regulatory factor-1. Kidney Int 67:1350-1361.

Y Fu, C Xie, J Zhu, J Thomas, XJ Zhou, and C Mohan. 2006. Innate immune nephritis – A novel experimentally induced murine nephritis model contingent upon FcR and Toll receptor stimulation and IL-1/TNF-a production. J Immunol 176: 632 – 639.

Xie C, Qin X, Jonnala G, Zhou XJ, and Mohan C. 2007. Enhanced immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol 124(1):49-56

Fu Y, Yong D and Mohan C. 2007. The experimental anti-GBM model as a tool for studying spontaneous lupus nephritis. Clin Immunol 124: 109-118

Xie C, Qin X, Xie S, Zhu J, Zhou XJ, and Mohan C. 2007. Strain distribution pattern of mice to anti-GBM nephritis – a follow up study. International Immunol (Acceptance pending revision).

T Wu, C Xie, HW Wang, XJ Zhou, N Schwartz, M Mackay, C Aranow, C Putterman, and C Mohan. 2007. Elevated urinary VCAM-1, P-selectin, sTNFR-1 and CXCL16 in multiple murine lupus strains and human lupus nephritis. J Immunol 179(10):7166-75

Li L. Mohan C. Genetic basis of murine lupus nephritis. Seminars in Nephrology. 27(1):12-21, 2007

Wu T. Xie C. Bhaskarabhatla M. Yan M. Leone A. Chen SS. Zhou XJ. Putterman C. Mohan C. Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance. Arthritis Rheum. 56(3):949-59, 2007

Wu TF, Mohan C. Three pathogenic determinants in immune nephritis – anti-glomerular antibody specificity, innate triggers and host genetics. Frontiers in Bioscience 12: 2207-2211, 2007

C Xie, ZSM Rahman, S Xie, J Zhu, Y Du, X Qin, H Zhou, XJ Zhou, and C Mohan. 2008. Strain distribution pattern of immune nephritis – a follow-up study. International Immunol 20(6):719-728.

Kui Liu, Quan-Zhen Li, Anna-Karin Abelson, Elena Sánchez, Jennifer A. Kelly, et al, and Mohan C. 2009. Kallikreins as disease genes in lupus and anti-glomerular antibody-induced nephritis. J Clin Invest 119(4): 911-923

Quan-Zhen Li, Jinchun Zhou, Ru Yang, Mei Yan, Qiu Ye, Kui Liu, Nancy Liu, Xinli Shao, Li Li, Ward Wakeland, and Chandra Mohan. 2009. The lupus susceptibility gene kallikrein down-modulates antibody-mediated glomerulonephritis. Genes Immunity 10(5):503-8.

Anna-Marie Fairhurst, Chun Xie, Yuyang Fu, Andrew Wang Christopher Boudreaux, Xin J Zhou, Ricardo Cibotti, Anthony Coyle, John E Connolly, Edward K. Wakeland, Chandra Mohan. 2009. Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis. J Immunol (183(10):6831-8

Tianfu Wu, Yuyang Fu, Deirdre Brekken, Columbine Che, Noa Schwartz, Ho Bing Oei, Xin J Zhou, Chul Ahn, Chaim Putterman and Chandra Mohan. 2010. Urine proteome scans uncover total urine protease as a potential marker of lupus nephritis. J Immunol 184(4):2183-93; PMID: 20065116

Y Du and Mohan. 2010. Pathogenesis of lupus nephritis. Book Chapter in “Systemic Lupus Erythematosus” by R. Lahita. 2010.

Lu H. Zhen J. Wu T. Peng A. Ye T. Wang T. Yu X. Vaziri ND. Mohan C. Zhou XJ. Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice. Am J Physiol 299(2):F445-52, 2010

Xie C, Liu K, Fu Y, Qin X, Jonnal G, Wang HW, Zhou XJ, Maldonado M, and C. Mohan. 2010. The chemokine RANTES is absolutely required for autoantibody induced glomerulonephritis. J Clin Immunol, DOI 10.1007/s10875-010-9470-x

Peng A. Wu T. Zeng C. Rakheja D. Zhu J. Ye T. Hutcheson J. Vaziri ND. Liu Z. Mohan C. Zhou XJ. Adverse effects of simulated hyper- and hypo-phosphatemia on endothelial cell function and viability.PLoS ONE 6(8):e23268, 2011.

Sandeep Singh, Tianfu Wu, Chun Xie, Kamala Vanarsa, Tina Mahajan, Ho Bing Oei, Chul Ahn, Joseph Zhou, Chaim Putterman, Ramesh Saxena and Chandra Mohan Urine VCAM1 as a marker of renal pathology activity index in lupus nephritis. Arthritis Research & Therapy 2012, 13;14(4):R164.

Ramesh Saxena, Tina Mahajan, Chandra Mohan. Lupus nephritis: current update. Arthritis Research & Therapy 2011, 13:240.

Peng A. Ye T. Rakheja D. Tu Y. Wang T. Du Y. Zhou JK. Vaziri ND. Hu Z. Mohan C. Zhou XJ. The green tea polyphenol (-)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis.Kidney International. 80(6):601-11, 2011.

Ozaltin F, Li B, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang C, Chen P, Lu D, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. DGKE Variants Cause a Glomerular Microangiopathy That Mimics Membranoproliferative GN. J Am Soc Nephrol. 2012 Dec 28.

Wu T, Mohan C. Lupus nephritis – alarmins may sound the alarm? Arthritis Res Ther. 2012 Dec 31;14(6):129.

Xinli Shao, Ru Yang, Mei Yan, Yajuan Li, Yong Du, Indu Ramin, Bo Zhang,Ward Wakeland, Peter Igarashi, Chandra Mohan*, Quan-Zhen Li* (* co-senior authors). Inducible expression of kallikrein in renal tubular cells protect mice from spontaneous lupus nephritis. 2012 Arthritis Rheum 2012 Dec 28. doi: 10.1002/art.37798.

Yong Du, Shion An, Li Liu, Ralph P Mason, Li Li, Xin J. Zhou , Chandra Mohan. Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging. 2012 PLOS ONE, E43941.doi:10.1371/journal.pone.0043941

Chun Xie, Yong Du , Kirthi Kumar, Li Li, Jie Han, Kui Liu, Xin J Zhou, and Chandra Mohan. Lupus prone strains vary in susceptibility to antibody-mediated end organ disease. Genes & Immunity 2013 Feb 7. doi: 10.1038/gene.2012.57.

Li Y, Raman I, Du Y, Yan M, Min S, Yang J, Fang X, Li W, Lu J, Zhou XJ, Mohan C*, Li QZ*. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress. PLoS One. 2013 Jul 23;8(7):e67790. (*Co-senior authors)

Guiyang Hao; Yong Du; Joseph Zhou; Orhan K. Öz; Chandra Mohan*; Xiankai Sun*. (*Co-senior authors). Longitudinal Non-invasive Assessment of Antibody Induced Nephritis in Mice using Positron Emission Tomography. PLOS One, 2013;8(2):e57418.

Wu T, Du Y, Han J, Singh S, Xie C, Guo Y, Zhou XJ, Ahn C, Saxena R, Mohan C. Urinary Angiostatin – a novel marker of renal pathology chronicity in lupus nephritis. Mol Cell Proteomics. 2013 Jan 23. [Epub ahead of print]

Wang S, Qin L, Wu T, Deng B, Sun Y, Hu D, Mohan C, Zhou XJ, Peng A. Elevated cardiac markers in chronic kidney disease as a consequence of hyperphosphatemia-induced cardiac myocyte injury. Med Sci Monit. 2014 Oct 25;20:2043-53. doi: 10.12659/MSM.890909.

Li Y, Li W, Liu C, Yan M, Raman I, Du Y, Fang X, Zhou XJ, Mohan C, Li QZ. Delivering Oxidation Resistance-1 (OXR1) to Mouse Kidney by Genetic Modified Mesenchymal Stem Cells Exhibited Enhanced Protection against Nephrotoxic Serum Induced Renal Injury and Lupus Nephritis. J Stem Cell Res Ther. 2014 Sep 10;4(9). pii: 231.

Hutcheson J, Ye Y, Han J, Arriens C, Saxena R, Li QZ, Mohan C, Wu T. Resistin as a potential marker of renal disease in lupus nephritis. Clin Exp Immunol. 2015 Mar;179(3):435-443. doi: 10.1111/cei.12473

Mohan C, Putterman C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol. 2015 Mar 31. doi: 10.1038/nrneph.2015.33. [Epub ahead of print] Review.PMID: 25825084

Li M, Du Y, Zhao F, Zeng J, Mohan C, Shih WC. Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS).Biomed Opt Express. 2015 Feb 19;6(3):849-58. doi: 10.1364/BOE.6.000849. eCollection 2015 Mar 1.PMID: 25798309 Free PMC Article

Ye T, Zhen J, Du Y, Zhou JK, Peng A, Vaziri ND, Mohan C, Xu Y, Zhou XJ. Green tea polyphenol (-)-epigallocatechin-3-gallate restores nrf2 activity and ameliorates crescentic glomerulonephritis. PLoS One. 2015 Mar 18;10(3):e0119543. doi: 10.1371/journal.pone.0119543. eCollection 2015.PMID: 25785827 Free PMC Article

Du Y, Sanam S, Kate K, Mohan C. Animal Models of Lupus and Lupus Nephritis. Curr Pharm Des. 2015 Mar 16. PMID: 25777751

Wang L, Wu J, Cheng JF, Liu XY, Ma F, Guo LH, Xu JM, Wu T, Mohan C, Peng A, Xu HX, Song YX. Diagnostic value of quantitative contrast-enhanced ultrasound (CEUS) for early detection of renal hyperperfusion in diabetic kidney disease. J Nephrol. 2015 Feb 25. PMID: 25712236

Wang L, Wu J, Cheng JF, Liu XY, Ma F, Guo LH, Xu JM, Wu T, Mohan C, Peng A, Xu HX, Song YX. Diagnostic value of quantitative contrast-enhanced ultrasound (CEUS) for early detection of renal hyperperfusion in diabetic kidney disease. J Nephrol. 2015 Feb 25. PMID: 25712236

Li J, Du Y, Qi J, Sneha R, Chang A, Mohan C, Shih WC. Raman spectroscopy as a diagnostic tool for monitoring acute nephritis. J Biophotonics. 2015 May 21. doi: 10.1002/jbio.201500109

Qin L, Tang B, Deng B, Mohan C, Wu T, Peng A. Extracellular regulated protein kinases play a key role via bone morphogenetic protein 4 in high phosphate-induced endothelial cell apoptosis. Life Sci. 2015 Jun 15;131:37-43. doi: 10.1016/j.lfs.2015.03.017.

Chun Xie, Tianfu Wu, Jie Han, Yujin Ye, Sandeep Singh, Joseph Zhou, Ramesh Saxena, and Chandra Mohan. Insulin-like Growth Factor Binding Protein-4 as a Marker of Concurrent Chronic Lupus Nephritis. 2015 (under review)

Yong Du, Chun Xie, Serigo Calixta, Sneha Ravikumar, Li Li, Xin J Zhou, and Chandra Mohan. Heightened experimental nephritis in 129×1/svJ strain is regulated by Smad3. 2015 (Under Review)

Li Li, Yong Du, Satyavani Nukala, Yang Liu, Jie Han, Hasna Kanta1, Xinjin Zhou , Anthony Chang, Trine N. Jørgensen, Brian L. Kotzin, Chandra Mohan. Nba1 on distal murine chromosome 4 impacts nephritis in a myeloid cell-dependent manner. 2015 (Under Review)

CC Mok, HH Ding, M Kharboutli and. C Mohan. sAxl, sTNFR2, ferritin and IGFBP-2 and as biomarkers in systemic lupus erythematosus. 2015 (Under Review)