Mohan Lab Publications

2020 

(undergraduate studentsgraduate studentsfellows)

Soomro S, Venkateswaran S, Vanarsa K, Kharboutli M, Nidhi M, Susarla R, Zhang T, Sasidharan P, Lee KH, Rosh J, Markowitz J, Pedroza C, Denson LA, Hyams J, Kugathasan S and Mohan C. Clinical utility of predicting disease course in pediatric ulcerative colitis using panels of stool proteins arising from a novel aptamer based screen. 2020 (under review)

Hao Li,  Vanarsa K, Zhang TSoomro S, Cicalese PA, Duran VDasari S, Lee KH, Pedroza C, Kisiel JB, Qin H,  Bresalier RS, Chia N, Mohan C. Comprehensive aptamer-based screen of 1317 proteins uncovers improved stool protein markers of colorectal cancer. 2020 (under review)

Cicalese Pietro Antonio, Aryan Mobiny, Pengyu Yuan, Jan Becker, Chandra Mohan, and Hien Van Nguyen. “StyPath: Style-Transfer Data Augmentation For Robust Histology Image Classification.” MICCAI (2020).

Ganugula R, Arora M, Zou D, Agarwal SK, Mohan C, Kumar MNVR. A highly potent lymphatic system-targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus. Sci Adv. 2020 Jun;6(24):eabb3900. doi: 10.1126/sciadv.abb3900. eCollection 2020 Jun. PubMed PMID: 32582860; PubMed Central PMCID: PMC7292630.

Vanarsa K, Henderson J, Soomro S, Qin L, Zhang T, Jordan N, Putterman C, Blanco I, Saxena R, Mohan C. Upregulation of Proinflammatory Bradykinin Peptides in Systemic Lupus Erythematosus and Rheumatoid Arthritis. J Immunol. 2020 Jul 15;205(2):369-376. doi: 10.4049/jimmunol.1801167. Epub 2020 Jun 15. PubMed PMID: 32540998.

Zhang T, Mohan C. Caution in studying and interpreting the lupus metabolome. Arthritis Res Ther. 2020 Jul 17;22(1):172. doi: 10.1186/s13075-020-02264-2. Review. PubMed PMID: 32680552; PubMed Central PMCID: PMC7367412.

Wu T, Marakkath B, Ye Y, Khobahy E, Yan M, Hutcheson J, Zhu J, Zhou X, Mohan C. Curcumin Attenuates Both Acute and Chronic Immune Nephritis. Int J Mol Sci. 2020 Mar 4;21(5):1745. doi: 10.3390/ijms21051745. PMID: 32143311

Becker JU, Mayerich D, Padmanabhan M, Barratt J, Ernst A, Boor P, Cicalese PA, Mohan C, Nguyen HV, Roysam B. Artificial intelligence and machine learning in nephropathology. Kidney Int. 2020 Jul;98(1):65-75. doi: 10.1016/j.kint.2020.02.027. Epub 2020 Apr 1. Review. PubMed PMID: 32475607.

Stanley S, Vanarsa K, Soliman S, Habazi D, Pedroza C, Gidley G, Zhang T, Mohan S, Der E, Suryawanshi H, Tuschl T, Buyon J, Putterman C, Mok CC, Petri M, Saxena R, Mohan C. Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities. Nat Commun. 2020 May 4;11(1):2197. doi: 10.1038/s41467-020-15986-3. PMID: 32366845

Fava A, Buyon JP, Mohan C, Zhang T, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine DM, Zhang Y, Magder L, Rao DA, Arazi A, Berthier CC, Davidson A, Diamond B, Hacohen N, Wofsy D, Apruzzese W, Accelerating Medicines Partnership T, Raychaudhuri S, Petri M. Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis. JCI Insight. 2020 May 12:138345. doi: 10.1172/jci.insight.138345.

Ding H, Lin C, Cai J, Guo Q, Dai M, Mohan C, Shen N. Urinary activated leukocyte cell adhesion molecule as a novel biomarker of lupus nephritis histology. Arthritis Res Ther. 2020 May 27;22(1):122. doi: 10.1186/s13075-020-02209-9. PubMed PMID: 32460901; PubMed Central PMCID: PMC7251704.

Zhang T, Li H, Vanarsa K, Gidley G, Mok CC, Petri M, Saxena R, Mohan C. Association of Urine sCD163 With Proliferative Lupus Nephritis, Fibrinoid Necrosis, Cellular Crescents and Intrarenal M2 Macrophages. Front Immunol. 2020 Apr 15;11:671. doi: 10.3389/fimmu.2020.00671. eCollection 2020. PMID: 32351512

Kamala Vanarsa, Sanam Soomro, Briony C. Strachan, Claudia Pedroza, Ting Zhang, Malavika Nidhi, Pietro Cicalese, Christopher Gidley, , Shree Mohan, Nathan Thai, Michelle Petri, Chandra Mohan. Quantitative planar array screens of 1000 proteins uncovers novel urinary protein biomarkers of lupus nephritis. Annals Rheum Dis 2020 (in press)

Victor Tedesco, Majid Ghoddus, Chandra Mohan. Biomarkers for Predicting CAR T-cell Therapy Toxicity. 2020 (under review)

Rahman Z and Mohan C. What do mouse models teach us about human SLE? In: Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects, 2nd Edition. 2020 (In Press)

Lei R, Huo R, Mohan C. Current and emerging trends in point-of-care urinalysis tests. Expert Rev Mol Diagn. 2020 doi: 10.1080/14737159.2020.1699063.

Anders H, Saxena R, Zhao M, Parodis I, Mohan C. Lupus Nephritus. Nature Reviews Diesease Primers. 2020 doi: 10.1038/s41572-019-0141-9

2019
Parodis I, Gokaraju S, Zickert A, Vanarsa K, Zhang T, Habazi D, Botto J, Serdoura Alves C, Giannopoulos P, Larsson A, Svenungsson E, Gunnarsson I, Mohan C. ALCAM and VCAM-1 as urine biomarkers of activity and long-term renal outcome in systemic lupus erythematosus. Rheumatology (Oxford). 2019 Nov 13;. doi: 10.1093/rheumatology/kez528.

Qiu J, Yuan Y, Li Y, Haley C, Mui UN, Swali R, Mohan C, Tyring SK, Wu T. Discovery of IgG4 Anti-Gliadin Autoantibody as a Potential Biomarker of Psoriasis Using an Autoantigen Array. Proteomics Clin Appl. 2019 Oct doi: 10.1002/prca.201800114.

Dasari S, Chakraborty A, Truong L, Mohan C. A Systematic Review of Interpathologist Agreement in Histologic Classification of Lupus Nephritis. Kidney Int Rep. 2019 Oct;4(10):1420-1425. doi: 10.1016/j.ekir.2019.06.011.

Zhou C, Li C, Wang Q, Wu M, Mohan C, Hu D, Peng A. Histopathological and proteomic analyses identify integrin-β1 as a potential mediator of phlebosclerosis in uremic patients. Clin Exp Nephrol. 2019 Sep;23(9):1100-1108. doi: 10.1007/s10157-019-01755-0.

Cao Q, Huang Q, Mohan C, Li C. Small-Animal PET/CT Imaging of Local and Systemic Immune Response Using 64Cu-αCD11b. J Nucl Med. 2019 Sep;60(9):1317-1324. doi: 10.2967/jnumed.118.220350.

Chang SH, Kim TJ, Kim Y, Han SS, Lee SK, Sim JH, Kim YJ, Lee SJ, Rhyu IJ, Nam KH, Mohan C, Kim HR. Impacts of GFP-FoxP3+ regulatory T cells on lupus hallmarks differ by genetic background and type of GFP knock-in. Autoimmunity. 2019 Aug – Sep;52(5-6):199-207. doi: 10.1080/08916934.2019.1657098.

Nguyen T, Payan B, Zambrano A, Du Y, Bondesson M, Mohan C. Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators. J Inflamm Res. 2019 Aug;12:231-239. doi: 10.2147/JIR.S224834.

Xu C, Yang X, Zhou H, Li Y, Xing C, Zhou T, Zhong D, Lian C, Yan M, Chen T, Liao Z, Gao B, Su D, Wang T, Sharma S, Mohan C, Ahituv N, Malik S, Li QZ, Su P. A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud. Genet Med. 2019 Aug 9;. doi: 10.1038/s41436-019-0626-7.

Ye Y, Wu T, Zhang T, Han J, Habazi D, Saxena R, Mohan C. Elevated oxidized lipids, anti-lipid autoantibodies and oxidized lipid immune complexes in active SLE. Clin Immunol. 2019 Aug;205:43-48. doi: 10.1016/j.clim.2019.05.004.

Nair A, Liu CH, Singh M, Das S, Le T, Du Y, Soomro S, Aglyamov S, Mohan C, Larin KV. Assessing colitis ex vivo using optical coherence elastography in a murine model. Quant Imaging Med Surg. 2019 Aug;9(8):1429-1440. doi: 10.21037/qims.2019.06.03

Du Y, Ding H, Vanarsa K, Soomro S, Baig S, Hicks J, Mohan C. Low Dose Epigallocatechin Gallate Alleviates Experimental Colitis by Subduing Inflammatory Cells and Cytokines, and Improving Intestinal Permeability. Nutrients. 2019 Jul. doi: 10.3390/nu11081743

Liu CH, Assassi S, Theodore S, Smith C, Schill A, Singh M, Aglyamov S, Mohan C, Larin KV. Translational optical coherence elastography for assessment of systemic sclerosis. J Biophotonics. 2019 Jul. doi: 10.1002/jbio.201900236.

QinL, Stanley S, Ding H, Zhang T, Truong VTT, Celhar T, Fairhurst A, Pedroza C, Petri , Saxena R, Mohan C. Urinary pro-thrombotic, anti-thrombotic, and fibrinolytic molecules as biomarkers of lupus nephritis.
2019 Jul. doi: 10.1186/s13075-019-1959-y

Luo H, Wang L, Bao D, Wang L, Zhao H, Lian Y, Yan M, Mohan C, Li QZ. Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus. Genomics Proteomics Bioinformatics. 2019 Jun;17(3):248-259. doi: 10.1016/j.gpb.2018.11.004.

Varadarajan N and Mohan C. Elucidating the molecular circuitry of autoimmunity. Nature Immunology. 2019 Jun. doi: 10.1038/s41590-019-0436-8

Chakraborty A, Dasari S, Long W, Mohan C. Urine protein biomarkers for the detection, surveillance, and treatment response prediction of bladder cancer. Am J Cancer Res. 2019 Jun;9(6):1104-1117.

Hou J, Du Y, Zhang T, Mohan C, Varghese OK. PEGylated (NH4)xWO3 nanorod mediated rapid photonecrosis of breast cancer cells. Nanoscale. 2019 May 30;11(21):10209-10219. doi: 10.1039/c9nr01077g.

Yang M, Akbar U, Mohan C. Curcumin in Autoimmune and Rheumatic Diseases.https://www.ncbi.nlm.nih.gov/pubmed/31052496 Nutrients. 2019 May 2;11(5). doi: 10.3390/nu11051004

Mahendra A, Yang X, Abnouf S, Adolacion JRT, Park D, Soomro S, Roszik J, Coarfa C, Romain G, Wanzeck K, Bridges SL Jr, Aggarwal A, Qiu P, Agarwal SK, Mohan C, Varadarajan N. Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing. Arthritis Rheumatol. 2019 Apr. doi: 10.1002/art.40772.

Parodis I, Ding H, Zickert A, Cosson G, Fathima M, Grönwall C, Mohan C, Gunnarsson I. Serum Axl predicts histology-based response to induction therapy and long-term renal outcome in lupus nephritis. PLoS One. 2019 Feb. doi: 10.1371/journal.pone.0212068.

Mike EV, Makinde HM, Gulinello M, Vanarsa K, Herlitz L, Gadhvi G, Winter DR, Mohan C, Hanly JG, Mok CC, Cuda CM, Putterman C. Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus. J Autoimmun. 2019 Jan.  doi: 10.1016/j.jaut.2018.08.005.

Quin L, Du Y, Ding H, Haque A, Hicks J, Pedroza C, Mohan C. Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis. Arthritis Research & therapy. 2019 Jan. doi: 10.1186/s13075-018-1774-x

Stanley S, Mok CC, Vanarsa K, Habazi D, Li J, Predoza C, Saxena R, Mohan C. Identification of Low-Abundance Urinary Biomarkers in Lupus Nephritis using Electrochemiluminescence Immunoassays.  Arthritis & Rheumatology 2019 Jan. doi: 10.1002/art.40813

2018

Mahendra A, Yang X, Abnouf S, Adolacion JRT, Park D, Soomro S, Roszik J, Coarfa C, Romain G, Wanzeck K, Louis Bridges S Jr, Aggarwal A, Qiu P, Agarwal SK, Mohan C, Varadarajan N. Beyond autoantibodies: Biological roles of human autoreactive B cells in rheumatoid arthritis revealed by RNA-sequencing. Arthritis Rheumatol. 2018 Nov 8. doi: 10.1002/art.40772.

Li M, Li X, Liu Y, Liu X, Song Y, Zhao J, Mohan C, Wu T, Peng A, Qin LRelationship between serum bilirubin levels and the progression of renal function in patients with chronic kidney disease and hyperuricemia. Clin Chim Acta. 2018 Nov;486:156-161. doi: 10.1016/j.cca.2018.07.045.

Mike EV, Makinde HM, Gulinello M, Vanarsa K, Herlitz L, Gadhvi G, Winter DR, Mohan C, Hanly JG, Mok CC, Cuda CM, Putterman C. Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus. J Autoimmun. 2018 Aug 30. pii: S0896-8411(18)30387-1. doi: 10.1016/j.jaut.2018.08.005.

Nair A, Liu CH, Das S, Ho T, Du Y, Soomro S, Mohan C, Larin KV. Detecting murine Inflammatory Bowel Disease using Optical Coherence Elastography. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:830-833. doi: 10.1109/EMBC.2018.8512295.

Mok, C. C., Soliman, S., Ho, L. Y., Mohamed, F. A., Mohamed, F. I., & Mohan, C. (2018). Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis. Arthritis research & therapy, 2018 Jan. doi: 10.1186/s13075-017-1498-3

Li, C., Hu, D., Xue, W., Li, X., Wang, Z., Ai, Z., … & Zhao, L. (2018). Treatment Outcome of Combined Continuous Venovenous Hemofiltration and Hemoperfusion in Acute Paraquat Poisoning: A Prospective Controlled Trial. Critical care medicine, 2018 Jan. doi: 10.1097/CCM.0000000000002826

2017
Soliman, S., Mohamed, F. A., Ismail, F. M., Stanley, S., Saxena, R., & Mohan, C. Urine angiostatin and VCAM‐1 surpass conventional metrics in predicting elevated renal pathology activity indices in lupus nephritis. International journal of rheumatic diseases. 2017 Nov. doi: 10.1111/1756-185X.13197

Akbar, U., Yang, M., Kurian, D., & Mohan, C. Omega-3 Fatty Acids in Rheumatic Diseases: A Critical Review. JCR: Journal of Clinical Rheumatology, 23(6), 330-339. 2017 Sep. . doi: 10.1097/RHU.0000000000000563

Selvam, A. P., Wangzhou, A., Jacobs, M., Wu, T., Mohan, C., & Prasad, S. Development and validation of an impedance biosensor for point-of-care detection of vascular cell adhesion molecule-1 toward lupus diagnostics. Future science OA,  2017 Jul. doi: 10.4155/fsoa-2017-0047

Mahendra, A., Yang, X., Abnouf, S., Park, D., Soomro, S., Adolacion, J. R., … & Bridges, S. L. Beyond Autoantibodies: Biological Roles Of Human Autoreactive B Cells In Rheumatoid Arthritis Revealed By Whole Transcriptome Profiling. bioRxiv, 2017 Jun. doi: 10.1002/art.40772

Oleksyn D, Zhao J, Vosoughi A, Zhao JC, Misra R, Pentland AP, Ryan D, Anolik J, Ritchlin C, Looney J, Anandarajah AP, Schwartz G, Calvi LM, Georger M, Mohan C, Sanz I, Chen L. PKK deficiency in B cells prevents lupus development in Sle lupus mice. Immunol Lett. 2017 May.  doi: 10.1016/j.imlet.2017.03.002.

Wu, M., Kang, X., Wang, Q., Zhou, C., Mohan, C., & Peng, A. Regulator of G protein signaling-1 modulates paraquat-induced oxidative stress and longevity via the insulin like signaling pathway in Caenorhabditis elegans. Toxicology letters, 2017 May. doi: 10.1016/j.toxlet.2017.03.027

Huynh, R. A., & Mohan, C. Alzheimer’s disease: biomarkers in the genome, blood, and cerebrospinal fluid. Frontiers in neurology, 2017 Mar. doi: 10.3389/fneur.2017.00102

Publications, by category, pre-2016:
Manuscripts on OMICS & Biomarkers
Manuscripts on Genetics
Manuscripts on B-cells & Antibodies
Manuscripts on Renal Disease
Manuscripts on Immunological Mechanisms of Autoimmunity
Manuscripts on Therapeutics & Natural Alternatives
Manuscripts on Non-invasive Diagnostics