Manuscripts on Immunological Mechanisms of Autoimmunity

Mohan C, Adams S, Stanik V, Datta SK. (1993). Nucleosomes: A major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 177:1367-1381.

Mohan C, Shi Y, Laman JD, Datta SK. (1995) Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J Immunol 154:1470-1480.

Mohan C, and Datta SK. (1995) Lupus: Key pathogenic mechanisms and contributing factors. Clin Immunol Immunopathol 77(3):209-220.

Datta SK, Mohan C, Desai-Mehta A. (1995) Mechanisms of the pathogenic autoimmune response in lupus: prospects for specific immunotherapy. Immunol Res 14:132-147.

Mohan C, Yu Y, Morel L, Yang P, Wakeland E.K. (1999). Genetic dissection of SLE pathogenesis: Sle3 impacts T-cell activation, differentiation and cell death. J Immunol 162:6492-6502

Shi X, Xie C, Kreska D, Richardson J, Mohan C. (2002) Genetic Dissection of SLE: Sle1 and Fas impact distinct pathways leading to lymphoproliferative autoimmunity. J Exp Med 196:281-292

Patel R and Mohan C. PI3K/AKT signaling and systemic autoimmunity. 2005. Immunol Res 31(1):47-55.

Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, and Mohan C. 2005. Genetic dissection of lupus: T-cell hyperactivity as a consequence of hyperstimulatory antigen presenting cells. J Clin Invest 115(7):1869-1878

Liu K. Mohan C. What do mouse models teach us about human SLE?. Clin Immunol. 119(2):123-30, 2006

Chun Xie, Rahul Patel, Tianfu Wu, Jiankun Zhu, Tamika Henry, Madhavi Bhaskarabhatla, Renuka Samudrala, Katalin Tus, Yimei Gong, Hui Zhou, Edward K. Wakeland, Xin J. Zhou, and Chandra Mohan. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr . International Immunol. 2007; 19: 509-522.

T Wu, X Qin, Liu K, Z Kurepa, M Bhaskarabhatla, XJ Zhou, Satterthwaite AB, LS Davis and C Mohan. 2007. Shared signaling networks that fire up in lupus B cells from genetically distinct mouse models – implications for disease pathogenesis and therapy. J Clin Invest 117: 2186 – 2196.

Jack Hutcheson, John C. Scatizzi, Akbar M. Siddiqui, G. Kenneth Haines, Tianfu Wu, Quan-Zhen Li, Laurie S. Davis, Chandra Mohan, and Harris Perlman. Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity. Immunity 2008 28: 206-217.

Andrew Wang, Anna-Marie Fairhurst, Katalin Tus, Srividya Subramanian, Yang Liu, Fangming Lin, Peter Igarashi1, Xin J. Zhou, Frederic Batteux, Donald Wong, Edward K.Wakeland, and Chandra Mohan. 2009. CXCR4/CXCL12 hyperexpression plays a pivotal role in lupus pathogenesis. J Immunol 182:4448-4458.

T Wu and Mohan C. 2009. The AKT axis as a therapeutic target in autoimmune diseases. Endocrine, Metabolic & ImmuneDisorders – Drug Targets. 9(2):145-50.

Chaim O Jacob, Jiankun Zhu, et al., and Mohan C. 2009. Identification of IRAK1 as a disease gene in systemic lupus erythematosus through combined forward genetic and reverse genetic approaches. Proc Natl Acad Sci USA 106(15):6256-61.

Chong BF. Mohan C. 2009. Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus. Expert Opinion on Therapeutic Targets. 13(10):1147-53.

A Wang, P Guilpain, B F. Chong, S Chouzenoux, L Guillevin, Y Du, X J. Zhou, F Lin, A Fairhurst, C Boudreaux, C Roux, EK. Wakeland, L Davis, Batteux, and C Mohan. 2010. Dysregulated Expression of CXCR4/CXCL12 in Subsets of Patients with Systemic Lupus Erythematosus. Arthritis Rheum 62: 3436–3446

Santiago-Raber ML. Dunand-Sauthier I. Wu T. Li QZ. Uematsu S. Akira S. Reith W. Mohan C. Kotzin BL. Izui S. Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice.. J Autoimmunity. 34(4):339-48, 2010

Jiankun Zhu, Chandra Mohan. Toll-like Receptor Signaling Pathway – Therapeutic Opportunities. Mediators of Inflammation. 2010:781235, 2010.

Davis LS. Hutcheson J. Mohan C. The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus. Journal of Interferon & Cytokine Research. 31(10):781-9, 2011.

Simanta Pathak, Chandra Mohan. Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models. Arthritis Research & Therapy 2011, 13:241.

Jacob Orme and Chandra Mohan. Macrophages and neutrophils in SLE—An online molecular catalog .Autoimmunity Reviews 2012; 11:365–372

Min SY. Fu Y. Hutcheson J. Wu T. Khobahy E. Zhu J. Vanarsa K. Du Y. Park MJ. Park HS. Saxena R. Kim HY. Mohan C. Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway.Clinical Immunology. 143(1):59-72, 2012.

Jacob Orme and Chandra Mohan. Macrophage Subpopulations in Systemic Lupus Erythematosus. Discovery Medicine 13: 151-158, 2012.

Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 1;191(5):2104-14.

Soyoun Min, Mei Yan, Yong Du, Tianfu Wu, Elhaum Khobahy, Seongryuel kwon, Cristina Arriens, Veena Taneja, Satyavani Nukala, Deena Sajitharan, Jacob Orme, Ho-Youn Kim, Chandra Mohan. Intra-articular injection of the selective IκB kinase β inhibitor NEMO-binding peptide ameliorates collagen-induced arthritis by inducing regulatory T cells and alternatively activated macrophages. Clin Exp Immunol. 2013 May;172(2):217-27. doi: 10.1111/cei.12054.

Becker AM, Dao KH, Han BK, Kornu R, Lakhanpal S, Mobley AB, Li QZ, Lian Y, Wu T, Reimold AM, Olsen NJ, Karp DR, Chowdhury FZ, Farrar JD, Satterthwaite AB, Mohan C, Lipsky PE, Wakeland EK, Davis LS. SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One. 2013 Jun 24;8(6):e67003.

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H. Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation. J Immunol. 2014 Jun 15;192(12):5548-60. doi: 10.4049/jimmunol.1400122. Epub 2014 May 7. PMID:24808358

Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E710-7. doi: 10.1073/pnas.1420217112. Epub 2015 Feb 2.

Mohan C, Putterman C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol. 2015 Mar 31. doi: 10.1038/nrneph.2015.33. [Epub ahead of print] Review.PMID: 25825084

Yong Du, Chandra Mohan. What do mouse models teach us about human SLE? IN: Systemic Lupus Erythematosus, edited by Dr. George Tsokos. Publisher: Life Science Academic Press/Elsevier. 2015 (In Press)

Jacob J. Orme, Yong Du, Kamala Vanarsa, Jessica Mayeux, Lisa Li, Azza Mutwally, Cristina Arriens, Soyoun Min, Laurie S. Davis, Benjamin F. Chong, Anne B. Satterthwaite, Tianfu Wu, Chandra Mohan. Heightened Cleavage of Axl Receptor Tyrosine Kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. 2015 (Under Review)