Mohan Lab Publications

Listed below are publications by Mohan Lab members, including undergraduate students, graduate students and fellows.

Publications by year:

2024

Reynolds JA, Li Y, Herlitz L, Mohan C, Putterman C. Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum. J Autoimmun. 2024 Jan;142:103134. doi: 10.1016/j.jaut.2023.103134. Epub 2023 Nov 7. PMID: 37944214; PMCID: PMC10957328. https://pubmed.ncbi.nlm.nih.gov/37944214/

Babalola KT, Arora M, Ganugula R, Agarwal SK, Mohan C, Kumar MNVR. Leveraging Lymphatic System Targeting in Systemic Lupus Erythematosus for Improved Clinical Outcomes. Pharmacol Rev. 2024 Feb 13;76(2):228-250. doi: 10.1124/pharmrev.123.000938. PMID: 38351070; PMCID: PMC10877736. https://pubmed.ncbi.nlm.nih.gov/38351070/

Li Y, Zhang S, Tang C, Yang B, Atrooz F, Ren Z, Mohan C, Salim S, Wu T. Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background. Front Immunol. 2024 Mar 8;15:1370254. doi: 10.3389/fimmu.2024.1370254. PMID: 38524134; PMCID: PMC10960363. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960363/

Gonawala L, Wijekoon N, Attanayake D, Ratnayake P, Sirisena D, Gunasekara H, Dissanayake A, Keshavaraj A, Mohan C, Steinbusch HWM, Hoffman EP, Dalal A, de Silva KRD. Diagnostic outcome of pro bono neurogenetic diagnostic service in Sri Lanka: A wealth creation. Eur J Hum Genet. 2024 Jan 23. doi: 10.1038/s41431-023-01525-3. Epub ahead of print. PMID: 38253783. https://pubmed.ncbi.nlm.nih.gov/38253783/

Ahmadi S, Ambite I, Brisuda A, Háček J, Haq F, Sabari S, Vanarsa K, Mohan C, Babjuk M, Svanborg C. Similar immune responses to alpha1-oleate and Bacillus Calmette-Guérin treatment in patients with bladder cancer. Cancer Med. 2024 Apr;13(7):e7091. doi: 10.1002/cam4.7091. PMID: 38553868; PMCID: PMC10980842. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10980842/

Reynolds J, Huang M, Li Y, Meineck M, Moeckel T, Weinmann-Menke J, Mohan C, Schwarting A, Putterman C. Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus. J Neuroinflammation. 2024 Apr 10;21(1):89. doi: 10.1186/s12974-024-03085-9. PMID: 38600510; PMCID: PMC11007930 https://pubmed.ncbi.nlm.nih.gov/38600510/

Rohith Appalaneni, Nikhila Achanta, Chandra Mohan. Chimeric antigen receptor T-cell therapy in rheumatology: B-cell depletion 2.0. Curr Opin Rheumatol. 2024 Mar 1;36(2):126-133. doi: 10.1097/BOR.0000000000000994. Epub 2023 Dec 15. https://pubmed.ncbi.nlm.nih.gov/38099466/

Ritu Bohat, Xiaofang Liang, Yanping Chen, Chunyu Xu, Ningbo Zheng, Ashley Guerrero, Jiakai Hou, Roshni Jaffery, Nicholas A. Egan, Yaxi Li, Yitao Tang, Esra Unsal, Adolfo Robles, Si Chen, Angela M. Major, Hadil Elldakli, Sanghyuk Chung, Liang Han, M. John Hicks, Yong Du, Jamie Lin, Xiqun Chen, Chandra Mohan, Weiyi Peng. FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus. Clin Immunol. 2024 Jan;258:109874. doi: 10.1016/j.clim.2023.109874. Epub 2023 Dec 17. PMID: 38113962. https://pubmed.ncbi.nlm.nih.gov/38113962/

Ji HL, Xi NMS, Mohan C, Yan X, Jain KG, Zang QS, Gahtan V, Zhao R. Biomarkers and molecular endotypes of sarcoidosis: lessons from omics and non-omics studies. Front Immunol. 2024 Jan 4;14:1342429. doi: 10.3389/fimmu.2023.1342429. PMID: 38250062; PMCID: PMC10797773. https://pubmed.ncbi.nlm.nih.gov/38250062/

Li Y, Tang C, Vanarsa K, Thai N, Castillo J, Lea GAB, Lee KH, Kim S, Pedroza C, Wu T, Saxena R, Mok CC, Mohan C. Proximity extension assay proteomics and renal single cell transcriptomics uncover novel urinary biomarkers for active lupus nephritis. J Autoimmun. 2024 Jan 8;143:103165. doi: 10.1016/j.jaut.2023.103165. Epub ahead of print. PMID: 38194790. https://pubmed.ncbi.nlm.nih.gov/38194790/

Rongwei Lei, Hufsa Arain, David Wang, Janani Arunachalam, Ramesh Saxena, Chandra Mohan. Duplex vertical flow rapid tests for point-of-care detection of anti-dsDNA and anti-nuclear autoantibodies. Biosensors 2024 Feb 12;14(2):98. doi:10.3390/bios14020098. https://pubmed.ncbi.nlm.nih.gov/38392017/

2023

Tripathy M., Bui A., Henderson J., Sun J., Woods C. Rutan, Somani S., Doan T., Louis Sam Titus A. Sam Crosslee, Mohan C. FAAH inhibition ameliorates breast cancer in a murine model. Oncotarget. 2023; 14: 910-918. Retrieved from https://www.oncotarget.com/article/28534/text/

https://www.oncotarget.net/2023/11/01/faah-inhibition-ameliorates-murine-breast-cancer/

Shen Y, Vanarsa K, Yin Z, Zhang T, Castillo J, Dai M, Zou L, Qin L, Wang J, Guo Q, Saxena R, Petri M, Shen N, Ye Z, Mohan C, Ding H. Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity. Front Immunol. 2023 Aug 31;14:1200167. doi: 10.3389/fimmu.2023.1200167.

http://journal.frontiersin.org/article/10.3389/fimmu.2023.1295153/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Immunology&id=1295153

Wijeweera G, Wijekoon N, Gonawala L, Imran Y, Mohan C, De Silva KRD. Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review. Evid Based Complement Alternat Med. 2023 Apr 13;2023:5583996. doi: 10.1155/2023/5583996. PMID: 37089709; PMCID: PMC10118888.

Reynolds JA, Li Y, Herlitz L, Mohan C, Putterman C. Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum. J Autoimmun. 2023 Nov 7;142:103134. doi: 10.1016/j.jaut.2023.103134. Epub ahead of print. PMID: 37944214. Wijekoon N, Gonawala L, Ratnayake P, Amaratunga D, Hathout Y, Mohan C, Steinbusch HWM, Dalal A, Hoffman EP, de Silva KRD. Duchenne Muscular Dystrophy from Brain to Muscle: The Role of Brain Dystrophin Isoforms in Motor Functions. J Clin Med. 2023 Aug 29;12(17):5637. doi: 10.3390/jcm12175637. PMID: 37685704; PMCID: PMC10488491.

Altini N, Rossini M, Turkevi-Nagy S, Pesce F, Pontrelli P, Prencipe B, Berloco F, Seshan S, Gibier JB, Pedraza Dorado A, Bueno G, Peruzzi L, Rossi M, Eccher A, Li F, Koumpis A, Beyan O, Barratt J, Vo HQ, Mohan C, Nguyen HV, Cicalese PA, Ernst A, Gesualdo L, Bevilacqua V, Becker JU. Performance and limitations of a supervised deep learning approach for the histopathological Oxford Classification of glomeruli with IgA nephropathy. Comput Methods Programs Biomed. 2023 Dec;242:107814. doi: 10.1016/j.cmpb.2023.107814. Epub 2023 Sep 13. PMID: 37722311.

Nan Xi, Chandra Mohan, Xiting Yan, Krishan G. Jain, Runzhen Zhao, Hong-Long (James) Ji. Biomarkers and Molecular Endotypes of Sarcoidosis: Lessons from Omics and non-Omics studies. Front. Immunol. Volume 14 – 2023 | doi: 10.3389/fimmu.2023.1342429

Kamala Vanarsa, , Jessica Castillo, Hao Li,, Kala T. Pham , Maria Akter, Sravya Gude , Kyung Hyun Lee, Claudia Pedroza, Robert Bresalier, Nicholas Chia, Chandra Mohan. High accuracy stool biomarkers of pre-cancerous colorectal cancer identified using a 2000-plex immunoproteomic screen. 2023 Mol Cell Proteomics.

Ranil De Silva, Lakmal Gonawala, Nalaka Wijekoon, Darshi Attanayake, Pyara Ratnayake, Darshana Sirisena, Harsha Gunasekara, Athula Dissanayake, Ajantha Keshavaraj, Chandra Mohan, Harry Steinbusch, Eric P Hoffman, and Ashwin Dala. Diagnostic Outcome of Pro bono neurogenetic diagnostic service in Sri Lanka: A Wealth Creation. European Journal of Human Genetics 2023, In Press

Mohan, C., Zhang, T. & Putterman, C. Pathogenic cellular and molecular mediators in lupus nephritis. Nat Rev Nephrol (2023). https://doi.org/10.1038/s41581-023-00722-z

Abhishek K, Nidhi M, Chandran S, Shevkoplyas SS, Mohan C. Manufacturing regulatory T cells for adoptive cell therapy in immune diseases: A critical appraisal. Clin Immunol. 2023 Apr 20;251:109328. doi: 10.1016/j.clim.2023.109328. Epub ahead of print. PMID: 37086957.

Inthavong H, Vanarsa K, Castillo J, Hicks MJ, Mohan C, Wenderfer SE. Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis. Rheumatology (Oxford). 2023 Mar 1;62(3):1335-1342. doi: 10.1093/rheumatology/keac465. PMID: 35961024; PMCID: PMC9977135.

Lindblom J, Toro-Domínguez D, Carnero-Montoro E, Beretta L, Borghi MO, Castillo J, Enman Y; PRECISESADS Clinical Consortium; Mohan C, Alarcón-Riquelme ME, Barturen G, Parodis I. Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus. J Autoimmun. 2023 Apr;136:103025. doi: 10.1016/j.jaut.2023.103025. Epub 2023 Mar 28. Erratum in: J Autoimmun. 2023 May 2;:103052. PMID: 36996699

Hwang M, Assassi S, Zheng J, Castillo J, Chavez R, Vanarsa K, Mohan C, Reveille J. Quantitative proteomic screening uncovers candidate diagnostic and monitoring serum biomarkers of ankylosing spondylitis. Arthritis Res Ther. 2023 Apr 11;25(1):57. doi: 10.1186/s13075-023-03044-4. PMID: 37041650; PMCID: PMC10088143.

Tang C, Zhang S, Teymur A, Yang B, Nazir F, Cai Q, Saxena R, Olsen NJ, Mohan C, Wu T. V-set Immunoglobulin-domain-containing 4 as a Novel Serum Biomarker of Lupus Nephritis and Renal Pathology Activity. Arthritis Rheumatol. 2023 May 10. doi: 10.1002/art.42545. Epub ahead of print. PMID: 37163449.

Louis Sam Titus ASC, Vanarsa K, Soomro S, Patel A, Prince J, Kugathasan S, Mohan C. Resistin, Elastase, and Lactoferrin as Potential Plasma Biomarkers of Pediatric Inflammatory Bowel Disease Based on Comprehensive Proteomic Screens. Mol Cell Proteomics. 2023 Feb;22(2):100487. doi: 10.1016/j.mcpro.2022.100487. Epub 2022 Dec 20. PMID: 36549591; PMCID: PMC9918796.

Wijekoon N, Gonawala L, Ratnayake P, Sirisena D, Gunasekara H, Dissanayake A, Senanayake S, Keshavaraj A, Hathout Y, Steinbusch HWM, Mohan C, Dalal A, Hoffman E, D de Silva KR. Gene therapy for selected neuromuscular and trinucleotide repeat disorders – An insight to subsume South Asia for multicenter clinical trials. IBRO Neurosci Rep. 2023 Jan 30;14:146-153. doi: 10.1016/j.ibneur.2023.01.009. PMID: 36819775; PMCID: PMC9931913.

Bellocchi C, Assassi S, Lyons M, Marchini M, Mohan C, Santaniello A, Beretta L. Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc. Arthritis Res Ther. 2023 Jan 27;25(1):15. doi: 10.1186/s13075-023-02989-w. PMID: 36707842; PMCID: PMC9881382.

Abhishek K, Louis Sam Titus ASC, Dinh MTP, Mukhamedshin A, Mohan C, Gifford SC, Shevkoplyas SS. Red blood cell rosetting enables size-based separation of specific lymphocyte subsets from blood in a microfluidic device. Lab Chip. 2023 Jan 25. doi: 10.1039/d2lc00817c. Epub ahead of print. PMID: 36723024.

Kamala Vanarsa; Jessica Castillo; Long Wang; Kyung Hyun Lee; Claudia Pedroza; Yair Lotan; Chandra Mohan. Comprehensive Proteomics and Platform Validation of Urinary Biomarkers for Bladder Cancer Diagnosis and Staging. BMC Medicine, 2023 BMC Med. 2023 Apr 5;21(1):133. doi: 10.1186/s12916-023-02813-x. PMID: 37016361; PMCID: PMC10074794.

Xie S, Louis Sam Titus ASC, Mohan C. Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys. Clin Immunol. 2023 Jan;246:109188. doi: 10.1016/j.clim.2022.109188. Epub 2022 Nov 15. PMID: 36396012.

Lei R, Thai N, Li Y, Petri M, Mohan C. Analytical validation of urine ALCAM ELISA as a test for lupus nephritis. Expert Rev Mol Diagn. 2023 Jul-Dec;23(8):729-738. doi: 10.1080/14737159.2023.2236022. Epub 2023 Jul 17. PMID: 37431809.

Louis Sam Titus ASC, Tan Y, Tran P, Lindblom J, Ivbievbiokun M, Xu Y, Zheng J, Parodis I, Cai Q, Chang A, Chen SH, Zhao M, Mohan C. Molecular architecture of proliferative lupus nephritis as elucidated using 50-plex imaging mass cytometry proteomics. Clin Immunol. 2023 Jul 27;254:109713. doi: 10.1016/j.clim.2023.109713. Epub ahead of print. PMID: 37516396.

Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Pulasthi Dissanayaka, Isuru Gunarathne, Dhammika Amaratunga, Roshan Liyanage, Sunethra Senanayaka, Saraji Wijesekara, Hemal H. Gunasekara, Kamala Vanarsa, Jessica Castillo, Yetrib Hathout Ashwin Dalal, Harry W.M. Steinbusch, Eric Hoffman, Chandra Mohan, K. Ranil D. de Silva. Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology,. Heliyon, Volume 9, Issue 8, e18530, 2023,

2022

Palazzo L, Lindblom J, Mohan C, Parodis I. Current Insights on Biomarkers in Lupus Nephritis: A Systematic Review of the Literature. J Clin Med. 2022 Sep 28;11(19):5759. doi: 10.3390/jcm11195759. PMID: 36233628; PMCID: PMC9570701.

Vu BV, Lei R, Mohan C, Kourentzi K, Willson RC. Flash Characterization of Smartphones Used in Point-of-Care Diagnostics. Biosensors (Basel). 2022 Nov 22;12(12):1060. doi: 10.3390/bios12121060. PMID: 36551027; PMCID: PMC9776052

Weeding E, Fava A, Mohan C, Magder L, Goldman D, Petri M. Urine proteomic insights from the belimumab in lupus nephritis trial. Lupus Sci Med. 2022 Sep;9(1):e000763. doi: 10.1136/lupus-2022-000763. PMID: 36167482; PMCID: PMC9516299.

Cho KB, Shukla SP, Kannan M, Zhang H, Amina SJ, Zhou S, Chen Y, Molligan JF, Taneja V, Mohan C, Udugamasooriya DG, Guo B. A peptoid interleukin-15 receptor antagonist suppresses inflammation and arthritis in mice. Clin Transl Immunology. 2022 Nov 24;11(11):e1432. doi: 10.1002/cti2.1432. PMID: 36439637; PMCID: PMC9686008.

Lei R, Vu B, Kourentzi K, Soomro S, Danthanarayana AN, Brgoch J, Nadimpalli S, Petri M, Mohan C, Willson RC. A novel technology for home monitoring of lupus nephritis that tracks the pathogenic urine biomarker ALCAM. Front Immunol. 2022 Dec 9;13:1044743. doi: 10.3389/fimmu.2022.1044743. PMID: 36569940; PMCID: PMC9780296.

Louis Sam Titus ASC, Vanarsa K, Soomro S, Patel A, Prince J, Kugathasan S, Mohan C. Resistin, Elastase and Lactoferrin as potential plasma biomarkers of Pediatric Inflammatory Bowel Disease based on Comprehensive Proteomic Screens. Mol Cell Proteomics. 2022 Dec 19:100487. doi: 10.1016/j.mcpro.2022.100487. Epub ahead of print. PMID: 36549591.

Kamala Vanarsa, Ting Zhang, Jack Hutcheson, Sneha Ravi Kumar, Satyavani Nukala, Haleigh Inthavong, Bruce Stanley, Tianfu Wu, Chi Chiu Mok, Ramesh Saxena, Chandra Mohan. iTRAQ-based mass spectrometry screen to identify serum biomarkers in systemic lupus erythematosus. Lupus Science & Medicine, October 2022

Rongwei Lei, Hufsa Arain, Maryam Obaid, Nivriti Sabhnani, Mohan Chandra. Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases. Biosensors 2022, 12, 756. https://doi.org/10.3390/bios12090756

Soliman SA, Stanley S, Vanarsa K, Ismail F, Mok CC, Mohan C. Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis. Front Immunol. 2022 Aug 24;13:910993. doi: 10.3389/fimmu.2022.910993. PMID: 36091001; PMCID: PMC9449537.

Dadras-Toussi O, Khorrami M, Louis Sam Titus ASC, Majd S, Mohan C, Abidian MR. Multiphoton Lithography of Organic Semiconductor Devices for 3D Printing of Flexible Electronic Circuits, Biosensors, and Bioelectronics. Adv Mater. 2022 Jul;34(30):e2200512. doi: 10.1002/adma.202200512. Epub 2022 Jun 16. PMID: 35707927; PMCID: PMC9339506.

Du Y, Lei L, Ding H, Chen Y, Pathak S, Hicks J, Tran PT, Wu M, Chang B, Wirtz U, Mohan C. Targeting Multiple End Organs in Lupus and Other Systemic Rheumatic Diseases by Inhibiting Bruton’s Tyrosine Kinase. Front Immunol. 2022 Jul 8;13:893899. doi: 10.3389/fimmu.2022.893899. PMID: 35874767; PMCID: PMC9304663.

Inthavong H, Vanarsa K, Castillo J, Hicks MJ, Mohan C, Wenderfer SE. Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis. Rheumatology (Oxford). 2022 Aug 12:keac465. doi: 10.1093/rheumatology/keac465. Epub ahead of print. PMID: 35961024.

Vanarsa K, Sasidharan P, Duran V, Gokaraju S, Nidhi M, Titus ASCLS, Soomro S, Stock AD, Der E, Putterman C, Greenberg B, Mok CC, Hanly JG, Mohan C. Aptamer-Based Screen of Neuropsychiatric Lupus Cerebrospinal Fluid Reveals Potential Biomarkers That Overlap With the Choroid Plexus Transcriptome. Arthritis Rheumatol. 2022 Jan 31. doi: 10.1002/art.42080.

Lei R, Wang D, Arain H, Mohan C. Design of Gold Nanoparticle Vertical Flow Assays for Point-of-Care Testing. Diagnostics (Basel). 2022 Apr 28;12(5):1107.

Chalmers SA, Ayilam Ramachandran R, Garcia SJ, Der E, Herlitz L, Ampudia J, Chu D, Jordan N, Zhang T, Parodis I, Gunnarsson I, Ding H, Shen N, Petri M, Mok CC, Saxena R, Polu KR, Connelly S, Ng CT, Mohan C, Putterman C. The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses. J Clin Invest. 2022 Jan 4;132(1):e147334

Baig S, Vanarsa K, Ding H, Titus ASCLS, McMahon M, Mohan C. Baseline Elevations of Leukotriene Metabolites and Altered Plasmalogens Are Prognostic Biomarkers of Plaque Progression in Systemic Lupus Erythematosus. Front Cardiovasc Med. 2022 May 16;9:861724. doi: 10.3389/fcvm.2022.861724.

Abunofal O, Mohan C. Salubrious Effects of Green Tea Catechins on Fatty Liver Disease: A Systematic Review. Medicines (Basel). 2022 Mar 1;9(3):20.

Zhang T, Du Y, Wu Q, Li H, Nguyen T, Gidley G, Duran V, Goldman D, Petri M, Mohan C. Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus. Arthritis Res Ther. 2022 Jan 3;24(1):3.

Li Y, Wang H, Zhang Z, Tang C, Zhou X, Mohan C, Wu T. Identification of polo-like kinase 1 as a therapeutic target in murine lupus. Clin Transl Immunology. 2022 Jan 6;11(1):e1362.

Ramasamy A, Dugyala P, Mohan C. Mobile health apps for systemic lupus erythematosus and lupus nephritis: a critical appraisal. Arthritis Res Ther. 2022 May 14;24(1):110.

Tang C, Fang M, Tan G, Zhang S, Yang B, Li Y, Zhang T, Saxena R, Mohan C, Wu T. Discovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics. Front Immunol. 2022 Mar 24;13:850015

Fava A, Rao DA, Mohan C, Zhang T, Rosenberg A, Fenaroli P, Belmont HM, Izmirly P, Clancy R, Trujillo JM, Fine D, Arazi A, Berthier CC, Davidson A, James JA, Diamond B, Hacohen N, Wofsy D, Raychaudhuri S, Apruzzese W; Accelerating Medicines Partnership in Rheumatoid Arthritis and Systemic Lupus Erythematosus Network, Buyon J, Petri M. Urine Proteomics and Renal Single-Cell Transcriptomics Implicate Interleukin-16 in Lupus Nephritis. Arthritis Rheumatol. 2022 May;74(5):829-839. doi: 10.1002/art.42023.

Lindblom J, Mohan C, Parodis I. Diagnostic, predictive and prognostic biomarkers in systemic lupus erythematosus: current insights. Curr Opin Rheumatol. 2022 Mar 1;34(2):139-149.

Lindblom J, Mohan C, Parodis I. Biomarkers in Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Literature Review of the Last Decade. Brain Sci. 2022 Jan 30;12(2):192

Samar A. Soliman, Anam Haque, Kamala Vanarsa, Ting Zhang, Faten Ismail, Kyung Hyun Lee, Claudia Pedroza, Larry A Greenbaum, Sherene Mason, M John Hicks, Scott E. Wenderfer, Chandra Mohan. Urine ALCAM, PF4 and VCAM-1 surpass conventional metrics in identifying nephritis disease activity in childhood-onset Systemic Lupus Erythematosus. Front Immunology 2022 June May 26;13:885307. doi: 10.3389/fimmu.2022.885307. eCollection 2022.

Sanam Soomro, Samantha Stanley, Rongwei Lei, Ramesh Saxena, Michelle Petri, Chandra Mohan. Comprehensive urinomic identification of protein alternatives to creatinine normalization for diagnostic assessment of lupus nephritis. Front Immunology 2022 June 14;13:853778. doi: 10.3389/fimmu.2022.853778. eCollection 2022

2021

Soomro S, Venkateswaran S, Vanarsa K, Kharboutli M, Nidhi M, Susarla R, Zhang T, Sasidharan P, Lee KH, Rosh J, Markowitz J, Pedroza C, Denson LA, Hyams J, Kugathasan S and Mohan C. Clinical utility of predicting disease course in pediatric ulcerative colitis using panels of stool proteins arising from a novel aptamer based screen. Nature Communication 2021 June 28, doi:10.1038/s41467-021-24235-0.

Hao Li, Vanarsa K, Zhang T, Soomro S, Cicalese PA, Duran V, Dasari S, Lee KH, Pedroza C, Kisiel JB, Qin H, Bresalier RS, Chia N, Mohan C. Comprehensive aptamer-based screen of 1317 proteins uncovers improved stool protein markers of colorectal cancer. J Gastroenterol. 2021 Jun 12. doi: 10.1007/s00535-021-01795-y. Epub ahead of print. PMID: 34117903.

Vanarsa K, Enan S, Patel P, Satrachan B, Sam Titus ASCL, Dennis A, Lotan Y, Mohan C. Urine protein biomarkers of bladder cancer arising from 16-plex antibody-based screens. Oncotarget. 2021 Apr 13;12(8):783-790. doi: 10.18632/oncotarget.27941. PMID: 33889301; PMCID: PMC8057279.

Cicalese Pietro Antonio, Aryan Mobiny, Pengyu Yuan, Jan Becker, Chandra Mohan, and Hien Van Nguyen. “StyPath: Style-Transfer Data Augmentation For Robust Histology Image Classification.” MICCAI (2021).

Soliman SA, Haque A, Mason S, Greenbaum LA, Hicks MJ, Mohan C, Wenderfer SE. Cross-sectional study of plasma Axl, ferritin, IGFBP4 and sTNFR2 as biomarkers of disease activity in childhood-onset SLE: A study of the Pediatric Nephrology Research Consortium. Lupus. 2021 May 14:9612033211016100. doi: 10.1177/09612033211016100. Epub ahead of print. PMID: 33990158

Victor Tedesco, Chandra Mohan. Biomarkers for Predicting CAR T-cell Therapy Toxicity. J Immunol. 2021 Apr 1;206(7):1561-1568. doi: 10.4049/jimmunol.2001249. Epub 2021 Mar 10. PMID: 33692146.

Cicalese PA, Mobiny A, Shahmoradi Z, Yi X, Mohan C, Van Nguyen H. Kidney Level Lupus Nephritis Classification Using Uncertainty Guided Bayesian Convolutional Neural Networks. IEEE J Biomed Health Inform. 2021 Feb;25(2):315-324. doi: 10.1109/JBHI.2020.3039162. Epub 2021 Feb 5. PMID: 33206612.

Du Y, Xie C, Ravikumar S, Orme J, Li L, Zhou XJ, Mohan C. Heightened Crescentic Glomerulonephritis in Immune Challenged 129sv Mice Is TGF-β/Smad3 Dependent. Int J Mol Sci. 2021 Feb 19;22(4):2059. doi: 10.3390/ijms22042059. PMID: 33669690; PMCID: PMC7922100.

Du Y, Paglicawan L, Soomro S, Abunofal O, Baig S, Vanarsa K, Hicks J, Mohan C. Epigallocatechin-3-Gallate Dampens Non-Alcoholic Fatty Liver by Modulating Liver Function, Lipid Profile and Macrophage Polarization. Nutrients. 2021 Feb 11;13(2):599. doi: 10.3390/nu13020599. PMID: 33670347; PMCID: PMC7918805.

Mok CC, Mohan C. Urinary Biomarkers in Lupus Nephritis: Are We There Yet? Arthritis Rheumatol. 2021 Feb;73(2):194-196. doi: 10.1002/art.41508. Epub 2021 Jan 13. PMID: 32892509.

Rahman Z and Mohan C. What do mouse models teach us about human SLE? In: Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects, 2nd Edition. 2021

Zhang T, Duran V, Vanarsa K, Mohan C. Targeted urine proteomics in lupus nephritis – a meta-analysis. Expert Rev Proteomics. 2021 Jan 19:1-10. doi: 10.1080/14789450.2020.1874356. Epub ahead of print. PMID: 33423575

Fava A, Rao DA, Mohan C, Zhang T, Rosenberg A, Fenaroli P, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine D, Arazi A, Berthier CC, Davidson A, James JA, Diamond B, Hacohen N, Wofsy D, Raychaudhuri S, Apruzzese W; Accelerating Medicines Partnership in RA/SLE network, Buyon J, Petri M. Urine Proteomics and Renal Single Cell Transcriptomics Implicate IL-16 in Lupus Nephritis. Arthritis Rheumatol. 2021 Nov 16. doi: 10.1002/art.42023. Epub ahead of print. PMID: 34783463

2020

Lei R, Mohan C. Immunological Biomarkers of COVID-19. Crit Rev Immunol. 2020;40(6):497-512. doi: 10.1615/CritRevImmunol.2020035652.33900694

Soliman S. and Mohan C. Urine Biomarkers for Lupus Nephritis: the Road Ahead. In: Clinical Laboratory Int. 2020. https://www.clinlabint.com/digital-editions/3d-issues/cli-october-2020/.

Ganugula R, Arora M, Zou D, Agarwal SK, Mohan C, Kumar MNVR. A highly potent lymphatic system-targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus. Sci Adv. 2020 Jun;6(24):eabb3900. doi: 10.1126/sciadv.abb3900. eCollection 2020 Jun. PubMed PMID: 32582860; PubMed Central PMCID: PMC7292630.

Vanarsa K, Henderson J, Soomro S, Qin L, Zhang T, Jordan N, Putterman C, Blanco I, Saxena R, Mohan C. Upregulation of Proinflammatory Bradykinin Peptides in Systemic Lupus Erythematosus and Rheumatoid Arthritis. J Immunol. 2020 Jul 15;205(2):369-376. doi: 10.4049/jimmunol.1801167. Epub 2020 Jun 15. PubMed PMID: 32540998.

Zhang T, Mohan C. Caution in studying and interpreting the lupus metabolome. Arthritis Res Ther. 2020 Jul 17;22(1):172. doi: 10.1186/s13075-020-02264-2. Review. PubMed PMID: 32680552; PubMed Central PMCID: PMC7367412.

Wu T, Marakkath B, Ye Y, Khobahy E, Yan M, Hutcheson J, Zhu J, Zhou X, Mohan C. Curcumin Attenuates Both Acute and Chronic Immune Nephritis. Int J Mol Sci. 2020 Mar 4;21(5):1745. doi: 10.3390/ijms21051745. PMID: 32143311

Becker JU, Mayerich D, Padmanabhan M, Barratt J, Ernst A, Boor P, Cicalese PA, Mohan C, Nguyen HV, Roysam B. Artificial intelligence and machine learning in nephropathology. Kidney Int. 2020 Jul;98(1):65-75. doi: 10.1016/j.kint.2020.02.027. Epub 2020 Apr 1. Review. PubMed PMID: 32475607.

Stanley S, Vanarsa K, Soliman S, Habazi D, Pedroza C, Gidley G, Zhang T, Mohan S, Der E, Suryawanshi H, Tuschl T, Buyon J, Putterman C, Mok CC, Petri M, Saxena R, Mohan C. Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities. Nat Commun. 2020 May 4;11(1):2197. doi: 10.1038/s41467-020-15986-3. PMID: 32366845

Fava A, Buyon JP, Mohan C, Zhang T, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine DM, Zhang Y, Magder L, Rao DA, Arazi A, Berthier CC, Davidson A, Diamond B, Hacohen N, Wofsy D, Apruzzese W, Accelerating Medicines Partnership T, Raychaudhuri S, Petri M. Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis. JCI Insight. 2020 May 12:138345. doi: 10.1172/jci.insight.138345.

Ding H, Lin C, Cai J, Guo Q, Dai M, Mohan C, Shen N. Urinary activated leukocyte cell adhesion molecule as a novel biomarker of lupus nephritis histology. Arthritis Res Ther. 2020 May 27;22(1):122. doi: 10.1186/s13075-020-02209-9. PubMed PMID: 32460901; PubMed Central PMCID: PMC7251704.

Zhang T, Li H, Vanarsa K, Gidley G, Mok CC, Petri M, Saxena R, Mohan C. Association of Urine sCD163 With Proliferative Lupus Nephritis, Fibrinoid Necrosis, Cellular Crescents and Intrarenal M2 Macrophages. Front Immunol. 2020 Apr 15;11:671. doi: 10.3389/fimmu.2020.00671. eCollection 2020. PMID: 32351512

Kamala Vanarsa, Sanam Soomro, Briony C. Strachan, Claudia Pedroza, Ting Zhang, Malavika Nidhi, Pietro Cicalese, Christopher Gidley, , Shree Mohan, Nathan Thai, Michelle Petri, Chandra Mohan. Quantitative planar array screens of 1000 proteins uncovers novel urinary protein biomarkers of lupus nephritis. Annals Rheum Dis 2020 Jul 10;. doi: 10.1136/annrheumdis-2019-216312.

Lei R, Huo R, Mohan C. Current and emerging trends in point-of-care urinalysis tests. Expert Rev Mol Diagn. 2020 doi: 10.1080/14737159.2020.1699063.

Anders H, Saxena R, Zhao M, Parodis I, Mohan C. Lupus Nephritus. Nature Reviews Diesease Primers. 2020 doi: 10.1038/s41572-019-0141-9.

Mok CC, Mohan C. Urinary Biomarkers in Lupus Nephritis: Are We There Yet? Arthritis Rheumatol. 2020 Sep 6. doi: 10.1002/art.41508.

Parodis I, Gokaraju S, Zickert A, Vanarsa K, Zhang T, Habazi D, Botto J, Serdoura Alves C, Giannopoulos P, Larsson A, Svenungsson E, Gunnarsson I, Mohan C. ALCAM and VCAM-1 as urine biomarkers of activity and long-term renal outcome in systemic lupus erythematosus. Rheumatology (Oxford). 2020 Sep 1;59(9):2237-2249. doi: 10.1093/rheumatology/kez528. PMID: 31722419; PMCID: PMC7449816.

Wijekoon N, Gonawala L, Wijesinghe P, Steinbusch HW, Mohan C, de Silva KRD. A biobank in Sri Lanka that links East and West. Lancet Neurol. 2020 Dec;19(12):972. doi: 10.1016/S1474-4422(20)30405-1. PMID: 33212058.

Ramanujam M, Steffgen J, Visvanathan S, Mohan C, Fine JS, Putterman C. Phoenix from the flames: Rediscovering the role of the CD40-CD40L pathway in systemic lupus erythematosus and lupus nephritis. Autoimmun Rev. 2020 Nov;19(11):102668. doi: 10.1016/j.autrev.2020.102668. Epub 2020 Sep 14. PMID: 32942031.

Cicalese PA, Mobiny A, Shahmoradi Z, Yi X, Mohan C, Nguyen HV. Kidney Level Lupus Nephritis Classification using Uncertainty Guided Bayesian Convolutional Neural Networks. IEEE J Biomed Health Inform. 2020 Nov 18;PP. doi: 10.1109/JBHI.2020.3039162. Epub ahead of print. PMID: 33206612.

Qiu J, Yuan Y, Li Y, Haley C, Mui UN, Swali R, Mohan C, Tyring SK, Wu T. Discovery of IgG4 Anti-Gliadin Autoantibody as a Potential Biomarker of Psoriasis Using an Autoantigen Array. Proteomics Clin Appl. 2020 Mar;14(2):e1800114. doi: 10.1002/prca.201800114. Epub 2019 Dec 11. PMID: 31671471

2019

Dasari S, Chakraborty A, Truong L, Mohan C. A Systematic Review of Interpathologist Agreement in Histologic Classification of Lupus Nephritis. Kidney Int Rep. 2019 Oct;4(10):1420-1425. doi: 10.1016/j.ekir.2019.06.011.

Zhou C, Li C, Wang Q, Wu M, Mohan C, Hu D, Peng A. Histopathological and proteomic analyses identify integrin-β1 as a potential mediator of phlebosclerosis in uremic patients. Clin Exp Nephrol. 2019 Sep;23(9):1100-1108. doi: 10.1007/s10157-019-01755-0.

Cao Q, Huang Q, Mohan C, Li C. Small-Animal PET/CT Imaging of Local and Systemic Immune Response Using 64Cu-αCD11b. J Nucl Med. 2019 Sep;60(9):1317-1324. doi: 10.2967/jnumed.118.220350.

Chang SH, Kim TJ, Kim Y, Han SS, Lee SK, Sim JH, Kim YJ, Lee SJ, Rhyu IJ, Nam KH, Mohan C, Kim HR. Impacts of GFP-FoxP3+ regulatory T cells on lupus hallmarks differ by genetic background and type of GFP knock-in. Autoimmunity. 2019 Aug – Sep;52(5-6):199-207. doi: 10.1080/08916934.2019.1657098.

Nguyen T, Payan B, Zambrano A, Du Y, Bondesson M, Mohan C. Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators. J Inflamm Res. 2019 Aug;12:231-239. doi: 10.2147/JIR.S224834.

Xu C, Yang X, Zhou H, Li Y, Xing C, Zhou T, Zhong D, Lian C, Yan M, Chen T, Liao Z, Gao B, Su D, Wang T, Sharma S, Mohan C, Ahituv N, Malik S, Li QZ, Su P. A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud. Genet Med. 2019 Aug 9;. doi: 10.1038/s41436-019-0626-7.

Ye Y, Wu T, Zhang T, Han J, Habazi D, Saxena R, Mohan C. Elevated oxidized lipids, anti-lipid autoantibodies and oxidized lipid immune complexes in active SLE. Clin Immunol. 2019 Aug;205:43-48. doi: 10.1016/j.clim.2019.05.004.

Nair A, Liu CH, Singh M, Das S, Le T, Du Y, Soomro S, Aglyamov S, Mohan C, Larin KV. Assessing colitis ex vivo using optical coherence elastography in a murine model. Quant Imaging Med Surg. 2019 Aug;9(8):1429-1440. doi: 10.21037/qims.2019.06.03

Du Y, Ding H, Vanarsa K, Soomro S, Baig S, Hicks J, Mohan C. Low Dose Epigallocatechin Gallate Alleviates Experimental Colitis by Subduing Inflammatory Cells and Cytokines, and Improving Intestinal Permeability. Nutrients. 2019 Jul. doi: 10.3390/nu11081743

Liu CH, Assassi S, Theodore S, Smith C, Schill A, Singh M, Aglyamov S, Mohan C, Larin KV. Translational optical coherence elastography for assessment of systemic sclerosis. J Biophotonics. 2019 Jul. doi: 10.1002/jbio.201900236.

QinL, Stanley S, Ding H, Zhang T, Truong VTT, Celhar T, Fairhurst A, Pedroza C, Petri , Saxena R, Mohan C. Urinary pro-thrombotic, anti-thrombotic, and fibrinolytic molecules as biomarkers of lupus nephritis.
2019 Jul. doi: 10.1186/s13075-019-1959-y

Luo H, Wang L, Bao D, Wang L, Zhao H, Lian Y, Yan M, Mohan C, Li QZ. Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus. Genomics Proteomics Bioinformatics. 2019 Jun;17(3):248-259. doi: 10.1016/j.gpb.2018.11.004.

Varadarajan N and Mohan C. Elucidating the molecular circuitry of autoimmunity. Nature Immunology. 2019 Jun. doi: 10.1038/s41590-019-0436-8

Chakraborty A, Dasari S, Long W, Mohan C. Urine protein biomarkers for the detection, surveillance, and treatment response prediction of bladder cancer. Am J Cancer Res. 2019 Jun;9(6):1104-1117.

Hou J, Du Y, Zhang T, Mohan C, Varghese OK. PEGylated (NH4)xWO3 nanorod mediated rapid photonecrosis of breast cancer cells. Nanoscale. 2019 May 30;11(21):10209-10219. doi: 10.1039/c9nr01077g.

Yang M, Akbar U, Mohan C. Curcumin in Autoimmune and Rheumatic Diseases.https://www.ncbi.nlm.nih.gov/pubmed/31052496 Nutrients. 2019 May 2;11(5). doi: 10.3390/nu11051004

Mahendra A, Yang X, Abnouf S, Adolacion JRT, Park D, Soomro S, Roszik J, Coarfa C, Romain G, Wanzeck K, Bridges SL Jr, Aggarwal A, Qiu P, Agarwal SK, Mohan C, Varadarajan N. Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing. Arthritis Rheumatol. 2019 Apr. doi: 10.1002/art.40772.

Parodis I, Ding H, Zickert A, Cosson G, Fathima M, Grönwall C, Mohan C, Gunnarsson I. Serum Axl predicts histology-based response to induction therapy and long-term renal outcome in lupus nephritis. PLoS One. 2019 Feb. doi: 10.1371/journal.pone.0212068.

Mike EV, Makinde HM, Gulinello M, Vanarsa K, Herlitz L, Gadhvi G, Winter DR, Mohan C, Hanly JG, Mok CC, Cuda CM, Putterman C. Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus. J Autoimmun. 2019 Jan. doi: 10.1016/j.jaut.2018.08.005.

Quin L, Du Y, Ding H, Haque A, Hicks J, Pedroza C, Mohan C. Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis. Arthritis Research & therapy. 2019 Jan. doi: 10.1186/s13075-018-1774-x

Stanley S, Mok CC, Vanarsa K, Habazi D, Li J, Predoza C, Saxena R, Mohan C. Identification of Low-Abundance Urinary Biomarkers in Lupus Nephritis using Electrochemiluminescence Immunoassays. Arthritis & Rheumatology 2019 Jan. doi: 10.1002/art.40813

2018

Mahendra A, Yang X, Abnouf S, Adolacion JRT, Park D, Soomro S, Roszik J, Coarfa C, Romain G, Wanzeck K, Louis Bridges S Jr, Aggarwal A, Qiu P, Agarwal SK, Mohan C, Varadarajan N. Beyond autoantibodies: Biological roles of human autoreactive B cells in rheumatoid arthritis revealed by RNA-sequencing. Arthritis Rheumatol. 2018 Nov 8. doi: 10.1002/art.40772.

Li M, Li X, Liu Y, Liu X, Song Y, Zhao J, Mohan C, Wu T, Peng A, Qin L. Relationship between serum bilirubin levels and the progression of renal function in patients with chronic kidney disease and hyperuricemia. Clin Chim Acta. 2018 Nov;486:156-161. doi: 10.1016/j.cca.2018.07.045.

Nair A, Liu CH, Das S, Ho T, Du Y, Soomro S, Mohan C, Larin KV. Detecting murine Inflammatory Bowel Disease using Optical Coherence Elastography. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:830-833. doi: 10.1109/EMBC.2018.8512295.

Mok, C. C., Soliman, S., Ho, L. Y., Mohamed, F. A., Mohamed, F. I., & Mohan, C. (2018). Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis. Arthritis research & therapy, 2018 Jan. doi: 10.1186/s13075-017-1498-3

Li, C., Hu, D., Xue, W., Li, X., Wang, Z., Ai, Z., … & Zhao, L. (2018). Treatment Outcome of Combined Continuous Venovenous Hemofiltration and Hemoperfusion in Acute Paraquat Poisoning: A Prospective Controlled Trial. Critical care medicine, 2018 Jan. doi: 10.1097/CCM.0000000000002826

2017

Soliman, S., Mohamed, F. A., Ismail, F. M., Stanley, S., Saxena, R., & Mohan, C. Urine angiostatin and VCAM‐1 surpass conventional metrics in predicting elevated renal pathology activity indices in lupus nephritis. International journal of rheumatic diseases. 2017 Nov. doi: 10.1111/1756-185X.13197

Akbar, U., Yang, M., Kurian, D., & Mohan, C. Omega-3 Fatty Acids in Rheumatic Diseases: A Critical Review. JCR: Journal of Clinical Rheumatology, 23(6), 330-339. 2017 Sep. . doi: 10.1097/RHU.0000000000000563

Selvam, A. P., Wangzhou, A., Jacobs, M., Wu, T., Mohan, C., & Prasad, S. Development and validation of an impedance biosensor for point-of-care detection of vascular cell adhesion molecule-1 toward lupus diagnostics. Future science OA, 2017 Jul. doi: 10.4155/fsoa-2017-0047

Mahendra, A., Yang, X., Abnouf, S., Park, D., Soomro, S., Adolacion, J. R., … & Bridges, S. L. Beyond Autoantibodies: Biological Roles Of Human Autoreactive B Cells In Rheumatoid Arthritis Revealed By Whole Transcriptome Profiling. bioRxiv, 2017 Jun. doi: 10.1002/art.40772

Oleksyn D, Zhao J, Vosoughi A, Zhao JC, Misra R, Pentland AP, Ryan D, Anolik J, Ritchlin C, Looney J, Anandarajah AP, Schwartz G, Calvi LM, Georger M, Mohan C, Sanz I, Chen L. PKK deficiency in B cells prevents lupus development in Sle lupus mice. Immunol Lett. 2017 May. doi: 10.1016/j.imlet.2017.03.002.

Wu, M., Kang, X., Wang, Q., Zhou, C., Mohan, C., & Peng, A. Regulator of G protein signaling-1 modulates paraquat-induced oxidative stress and longevity via the insulin like signaling pathway in Caenorhabditis elegans. Toxicology letters, 2017 May. doi: 10.1016/j.toxlet.2017.03.027

Huynh, R. A., & Mohan, C. Alzheimer’s disease: biomarkers in the genome, blood, and cerebrospinal fluid. Frontiers in neurology, 2017 Mar. doi: 10.3389/fneur.2017.00102

2015

Hutcheson J, Ye Y, Han J, Arriens C, Saxena R, Li QZ, Mohan C, Wu T. Resistin as a potential marker of renal disease in lupus nephritis. Clin Exp Immunol. 2015 Mar;179(3):435-443. doi: 10.1111/cei.12473

Dania Albaba , Sanam Soomro, and Chandra Mohan. Aptamer-based Screens of Human Body Fluids for Biomarkers. 2015 (Under Review)

Tianfu Wu, Huihua Ding, Jie Han, Cristina Arriens, Chungwen Wei, Weilu Han, Claudia Pedroza, Shan Jiang, Jennifer Anolik, Michelle Petri, Ignacio Sanz, Ramesh Saxena, Chandra Mohan. Antibody array based proteomic screening of erum markers in systemic lupus erythematosus. 2015 (Under Review)

CC Mok, HH Ding, M Kharboutli and. C Mohan. sAxl, sTNFR2, ferritin and IGFBP-2 and as biomarkers in systemic lupus erythematosus. 2015 (Under Review)

Tianfu Wu, Chun Xie, Jie Han, Yujin Ye, Sandeep Singh, Joseph Zhou, Ramesh Saxena, and Chandra Mohan. Insulin-like Growth Factor Binding Protein-4 as a Marker of Concurrent Chronic Lupus Nephritis. 2015 (under review)

Chandra Mohan, Shervin Assassi. Biomarkers in rheumatic diseases: How can they facilitate diagnosis and disease activity assessment? Brit Med J 2015 (In Press)

Minghua Wu, Chandra Mohan. B cells in Systemic Sclerosis: Emerging evidence from genetics to phenotypes. Curr Opin Rheumatology 2015 (In Press)

Mohan C, Putterman C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol. 2015 Mar 31. doi: 10.1038/nrneph.2015.33. [Epub ahead of print] Review.PMID: 25825084

Chang SH, Kim TJ, Kim YJ, Liu Y, Min SY, Park MJ, Park HS, Lee SK, Nam KH, Kim HY, Mohan C, Kim HR. The Lupus Susceptibility Locus Sle1 Facilitates the Peripheral Development and Selection of Anti-DNA B Cells through Impaired Receptor Editing. J Immunol. 2014 Jun 15;192(12):5579-85. doi: 10.4049/jimmunol.1201558. Epub 2014 May 16. PMID:24835399

Minghua Wu, Chandra Mohan. B cells in Systemic Sclerosis: Emerging evidence from genetics to phenotypes. Curr Opin Rheumatology 2015 (In Press)

Li M, Du Y, Zhao F, Zeng J, Mohan C, Shih WC. Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS).Biomed Opt Express. 2015 Feb 19;6(3):849-58. doi: 10.1364/BOE.6.000849. eCollection 2015 Mar 1.PMID: 25798309 Free PMC Article

Ye T, Zhen J, Du Y, Zhou JK, Peng A, Vaziri ND, Mohan C, Xu Y, Zhou XJ. Green tea polyphenol (-)-epigallocatechin-3-gallate restores nrf2 activity and ameliorates crescentic glomerulonephritis. PLoS One. 2015 Mar 18;10(3):e0119543. doi: 10.1371/journal.pone.0119543. eCollection 2015.PMID: 25785827 Free PMC Article

Du Y, Sanam S, Kate K, Mohan C. Animal Models of Lupus and Lupus Nephritis. Curr Pharm Des. 2015 Mar 16. PMID: 25777751

Wang L, Wu J, Cheng JF, Liu XY, Ma F, Guo LH, Xu JM, Wu T, Mohan C, Peng A, Xu HX, Song YX. Diagnostic value of quantitative contrast-enhanced ultrasound (CEUS) for early detection of renal hyperperfusion in diabetic kidney disease. J Nephrol. 2015 Feb 25. PMID: 25712236

Li J, Du Y, Qi J, Sneha R, Chang A, Mohan C, Shih WC. Raman spectroscopy as a diagnostic tool for monitoring acute nephritis. J Biophotonics. 2015 May 21. doi: 10.1002/jbio.201500109

Qin L, Tang B, Deng B, Mohan C, Wu T, Peng A. Extracellular regulated protein kinases play a key role via bone morphogenetic protein 4 in high phosphate-induced endothelial cell apoptosis. Life Sci. 2015 Jun 15;131:37-43. doi: 10.1016/j.lfs.2015.03.017.

Chun Xie, Tianfu Wu, Jie Han, Yujin Ye, Sandeep Singh, Joseph Zhou, Ramesh Saxena, and Chandra Mohan. Insulin-like Growth Factor Binding Protein-4 as a Marker of Concurrent Chronic Lupus Nephritis. 2015 (under review)

Yong Du, Chun Xie, Serigo Calixta, Sneha Ravikumar, Li Li, Xin J Zhou, and Chandra Mohan. Heightened experimental nephritis in 129×1/svJ strain is regulated by Smad3. 2015 (Under Review)

Li Li, Yong Du, Satyavani Nukala, Yang Liu, Jie Han, Hasna Kanta1, Xinjin Zhou , Anthony Chang, Trine N. Jørgensen, Brian L. Kotzin, Chandra Mohan. Nba1 on distal murine chromosome 4 impacts nephritis in a myeloid cell-dependent manner. 2015 (Under Review)

CC Mok, HH Ding, M Kharboutli and. C Mohan. sAxl, sTNFR2, ferritin and IGFBP-2 and as biomarkers in systemic lupus erythematosus. 2015 (Under Review)

Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E710-7. doi: 10.1073/pnas.1420217112. Epub 2015 Feb 2

Yong Du, Chandra Mohan. What do mouse models teach us about human SLE? IN: Systemic Lupus Erythematosus, edited by Dr. George Tsokos. Publisher: Life Science Academic Press/Elsevier. 2015 (In Press)

Jacob J. Orme, Yong Du, Kamala Vanarsa, Jessica Mayeux, Lisa Li, Azza Mutwally, Cristina Arriens, Soyoun Min, Laurie S. Davis, Benjamin F. Chong, Anne B. Satterthwaite, Tianfu Wu, Chandra Mohan. Heightened Cleavage of Axl Receptor Tyrosine Kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. 2015 (Under Review)

Cristina Arriens, Linda S. Hynan, Robert H. Lerman, David R. Karp, and Chandra Mohan. Placebo-Controlled Randomized Clinical Trial of Fish Oil’s Impact on Fatigue, Quality of Life, and Disease Activity in Systemic Lupus Erythematosus. 2015 Nutrition (In Press)

Bindiya Marakkath and Chandra Mohan. Can a plant derived compound provide a lupus lifeline?’ Future Science 2015 (In Press)

Wang L, Cheng JF, Sun LP, Song YX, Guo LH, Xu JM, Wu TF, Mohan C, Peng A, Xu HX, Liu X. Use of Contrast-Enhanced Ultrasound to Study Relationship between Serum Uric Acid and Renal Microvascular Perfusion in Diabetic Kidney Disease. Biomed Res Int. 2015;2015:732317. doi: 10.1155/2015/732317. Epub 2015

Kang X, Hu DY, Li CB, Li XH, Fan SL, Liu Y, Tang GY, Ai ZS, Wu T, Mohan C, Zhou XJ, Liu JY, Peng A. The volume ratio of ground glass opacity in early lung CT predicts mortality in acute paraquat poisoning. PLoS One. 2015 Apr 1;10(4):e0121691. doi: 10.1371/journal.pone.0121691

Li J, Du Y, Qi J, Sneha R, Chang A, Mohan C, Shih WC. Raman spectroscopy as a diagnostic tool for monitoring acute nephritis. J Biophotonics. 2015 May 21. doi: 10.1002/jbio.201500109

CC Mok, HH Ding, M Kharboutli and. C Mohan. sAxl, sTNFR2, ferritin and IGFBP-2 and as biomarkers in systemic lupus erythematosus. 2015 (Under Review)

2014

Wang S, Qin L, Wu T, Deng B, Sun Y, Hu D, Mohan C, Zhou XJ, Peng A. Elevated cardiac markers in chronic kidney disease as a consequence of hyperphosphatemia-induced cardiac myocyte injury. Med Sci Monit. 2014 Oct 25;20:2043-53. doi: 10.12659/MSM.890909

Arriens C, Mohan C. Systemic lupus erythematosus diagnostics in the ‘omics’ era. Int J Clin Rheumtol. 2014 Dec 1;8(6):671-687. PMID: 24860621

Li Y, Li W, Liu C, Yan M, Raman I, Du Y, Fang X, Zhou XJ, Mohan C, Li QZ. Delivering Oxidation Resistance-1 (OXR1) to Mouse Kidney by Genetic Modified Mesenchymal Stem Cells Exhibited Enhanced Protection against Nephrotoxic Serum Induced Renal Injury and Lupus Nephritis. J Stem Cell Res Ther. 2014 Sep 10;4(9). pii: 231

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H. Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation. J Immunol. 2014 Jun 15;192(12):5548-60. doi: 10.4049/jimmunol.1400122. Epub 2014 May 7. PMID:24808358

Wu T, Ye Y, Min SY, Zhu J, Khobahy E, Zhou J, Yan M, Hemachandran S, Pathak S, Zhou XJ, Andreeff M, Mohan C. Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid. Arthritis Rheumatol. 2014 Nov;66(11):3129-39. doi: 10.1002/art.38782

2013

Wu T, Du Y, Han J, Singh S, Xie C, Guo Y, Zhou XJ, Ahn C, Saxena R, Mohan C. Urinary Angiostatin – a novel marker of renal pathology chronicity in lupus nephritis. Mol Cell Proteomics. 2013 Jan 23. [Epub ahead of print]

Becker AM, Dao KH, Han BK, Kornu R, Lakhanpal S, Mobley AB, Li QZ, Lian Y, Wu T, Reimold AM, Olsen NJ, Karp DR, Chowdhury FZ, Farrar JD, Satterthwaite AB, Mohan C, Lipsky PE, Wakeland EK, Davis LS. SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One. 2013 Jun 24;8(6):e67003

Richardson C, Chida AS, Adlowitz D, Silver L, Fox E, Jenks SA, Palmer E, Wang Y, Heimburg-Molinaro J, Li QZ, Mohan C, Cummings R, Tipton C, Sanz I.Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus Erythematosus. J Immunol. 2013 Oct 9. [Epub ahead of print]

Chun Xie, Yong Du , Kirthi Kumar, Li Li, Jie Han, Kui Liu, Xin J Zhou, and Chandra Mohan. Lupus prone strains vary in susceptibility to antibody-mediated end organ disease. Genes & Immunity 2013 Feb 7. doi: 10.1038/gene.2012.57

Li Y, Raman I, Du Y, Yan M, Min S, Yang J, Fang X, Li W, Lu J, Zhou XJ, Mohan C*, Li QZ*. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress. PLoS One. 2013 Jul 23;8(7):e67790. (*Co-senior authors)

Guiyang Hao; Yong Du; Joseph Zhou; Orhan K. Öz; Chandra Mohan*; Xiankai Sun*. (*Co-senior authors). Longitudinal Non-invasive Assessment of Antibody Induced Nephritis in Mice using Positron Emission Tomography. PLOS One, 2013;8(2):e57418

Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 1;191(5):2104-14

Soyoun Min, Mei Yan, Yong Du, Tianfu Wu, Elhaum Khobahy, Seongryuel kwon, Cristina Arriens, Veena Taneja, Satyavani Nukala, Deena Sajitharan, Jacob Orme, Ho-Youn Kim, Chandra Mohan. Intra-articular injection of the selective IκB kinase β inhibitor NEMO-binding peptide ameliorates collagen-induced arthritis by inducing regulatory T cells and alternatively activated macrophages. Clin Exp Immunol. 2013 May;172(2):217-27. doi: 10.1111/cei.12054

2012

Sandeep Singh, Tianfu Wu, Chun Xie, Kamala Vanarsa, Tina Mahajan, Ho Bing Oei, Chul Ahn, Joseph Zhou, Chaim Putterman, Ramesh Saxena and Chandra Mohan Urine VCAM1 as a marker of renal pathology activity index in lupus nephritis. Arthritis Research & Therapy 2012, 13;14(4):R164

Tianfu Wu, Chun Xie, Jie Han, Jim Weiel, Quan Li, Irene Blanco, Chul Ahn, Nancy Olsen, Chaim Putterman, Ramesh Saxena, Chandra Mohan. METABOLIC DISTURBANCES UNDERLYING SYSTEMIC LUPUS ERYTHEMATOSUS. 2012. PLOS ONE . 7(6): p. e37210

Vanarsa K, Ye Y, Han J, Xie C, Mohan C*, Wu T*. Inflammation associated anemia and ferritin as disease markers in SLE. Arthritis Res Ther. 2012 Aug 7;14(4):R182. PMID:22871034

Kiani AN, Wu T, Fang H, Zhou XJ, Ahn CW, Magder LS, Mohan C*, Petri M*. (*Co-senior authors). Urinary vascular cell adhesion molecule, but not neutrophil gelatinase-associated lipocalin, is associated with lupus nephritis. J Rheumatol. 2012 Jun;39(6):1231-7. Epub 2012 Apr 15

J Hutcheson, D Sajitharan, K Vanarsa and C Mohan. Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus. Arthritis Research & Therapy 2012, 8;14(6):R243

Wong EB, Khan TN, Mohan C, Rahman ZS. The Lupus-Prone NZM2410/NZW Strain-Derived Sle1b Sublocus Alters the Germinal Center Checkpoint in Female Mice in a B Cell-Intrinsic Manner. J Immunol. 2012 Nov 9. PMID: 23144494

Chong BF, Tseng LC, Lee T, Vasquez R, Li QZ, Zhang S, Karp DR, Olsen NJ, Mohan C. IgG and IgM Autoantibody Differences in Discoid and Systemic Lupus Patients. J Invest Dermatol. 2012 Jul 5. doi: 10.1038/jid.2012.207

Li L, Nukala S, Du Y, Han J, Liu K, Hutcheson J, Pathak S, Li Q, Mohan C. Murine lupus strains differentially model unique facets of human lupus serology. Clin Exp Immunol. 2012 May;168(2):178-85. doi: 10.1111/j.1365-2249.2012.04568.x. PMID:22471278

Oleksyn D, Pulvino M, Zhao J, Misra R, Vosoughi A, Jenks S, Tipton C, Lund F, Schwartz G, Goldman B, Mohan C, Mehta K, Mehta M, Leitgets M, Sanz I, Chen L. PKCβ is required for lupus development in Sle mice. Arthritis Rheum. 2012 Dec 21. doi: 10.1002/art.37825

Ozaltin F, Li B, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang C, Chen P, Lu D, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. DGKE Variants Cause a Glomerular Microangiopathy That Mimics Membranoproliferative GN. J Am Soc Nephrol. 2012 Dec 28

Wu T, Mohan C. Lupus nephritis – alarmins may sound the alarm? Arthritis Res Ther. 2012 Dec 31;14(6):129

Xinli Shao, Ru Yang, Mei Yan, Yajuan Li, Yong Du, Indu Ramin, Bo Zhang,Ward Wakeland, Peter Igarashi, Chandra Mohan*, Quan-Zhen Li* (* co-senior authors). Inducible expression of kallikrein in renal tubular cells protect mice from spontaneous lupus nephritis. 2012 Arthritis Rheum 2012 Dec 28. doi: 10.1002/art.37798

Yong Du, Shion An, Li Liu, Ralph P Mason, Li Li, Xin J. Zhou , Chandra Mohan. Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging. 2012 PLOS ONE, E43941.doi:10.1371/journal.pone.0043941

Jacob Orme and Chandra Mohan. Macrophages and neutrophils in SLE—An online molecular catalog .Autoimmunity Reviews 2012; 11:365–372

Min SY. Fu Y. Hutcheson J. Wu T. Khobahy E. Zhu J. Vanarsa K. Du Y. Park MJ. Park HS. Saxena R. Kim HY. Mohan C. Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway.Clinical Immunology. 143(1):59-72, 2012

Jacob Orme and Chandra Mohan. Macrophage Subpopulations in Systemic Lupus Erythematosus. Discovery Medicine 13: 151-158, 2012

Vanarsa K, Ye Y, Han J, Xie C, Mohan C*, Wu T*. Inflammation associated anemia and ferritin as disease markers in SLE. Arthritis Res Ther. 2012 Aug 7;14(4):R182. PMID:22871034

2011

Peng A. Wu T. Zeng C. Rakheja D. Zhu J. Ye T. Hutcheson J. Vaziri ND. Liu Z. Mohan C. Zhou XJ. Adverse effects of simulated hyper- and hypo-phosphatemia on endothelial cell function and viability.PLoS ONE 6(8):e23268, 2011

Ramesh Saxena, Tina Mahajan, Chandra Mohan. Lupus nephritis: current update. Arthritis Research & Therapy 2011, 13:240

Peng A. Ye T. Rakheja D. Tu Y. Wang T. Du Y. Zhou JK. Vaziri ND. Hu Z. Mohan C. Zhou XJ. The green tea polyphenol (-)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis.Kidney International. 80(6):601-11, 2011

Davis LS. Hutcheson J. Mohan C. The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosus. Journal of Interferon & Cytokine Research. 31(10):781-9, 2011

Simanta Pathak, Chandra Mohan. Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models. Arthritis Research & Therapy 2011, 13:241

2010

Tianfu Wu, Yuyang Fu, Deirdre Brekken, Columbine Che, Noa Schwartz, Ho Bing Oei, Xin J Zhou, Chul Ahn, Chaim Putterman and Chandra Mohan. 2010. Urine proteome scans uncover total urine protease as a potential marker of lupus nephritis. J Immunol 184(4):2183-93; PMID: 20065116

Li QZ. Zhou J. Lian Y. Zhang B. Branch VK. Carr-Johnson F. Karp DR. Mohan C. Wakeland EK. Olsen NJ. 2010. Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes. Clin Exp Immunol. 159(3):281-91, 2010

Tianfu Wu, Deena Sajitharan& Chandra Mohan. Biomarkers of rheumatoid arthritis: recent progress. Expert Opinion on Medical Diagnostics. 2010. 4(4): 293-305

Kamala Vanarsa, Chandra Mohan. 2010. Proteomics in rheumatology: the dawn of a new era. F1000 Medicine Reports 2010 2:(87)

A.B. Satterthwaite & C Mohan. Genetics: Rare genes for autoimmunity—the new kids on the block. Nature Reviews Rheumatology 6, 678-679; 2010

Peters AL. Stunz LL. Meyerholz DK. Mohan C. Bishop GA. Latent membrane protein 1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.Sle1 mice.J Immunol. 185(7):4053-62, 2010

Y Du and Mohan. 2010. Pathogenesis of lupus nephritis. Book Chapter in “Systemic Lupus Erythematosus” by R. Lahita. 2010

Lu H. Zhen J. Wu T. Peng A. Ye T. Wang T. Yu X. Vaziri ND. Mohan C. Zhou XJ. Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice. Am J Physiol 299(2):F445-52, 2010

Xie C, Liu K, Fu Y, Qin X, Jonnal G, Wang HW, Zhou XJ, Maldonado M, and C. Mohan. 2010. The chemokine RANTES is absolutely required for autoantibody induced glomerulonephritis. J Clin Immunol, DOI 10.1007/s10875-010-9470-x

A Wang, P Guilpain, B F. Chong, S Chouzenoux, L Guillevin, Y Du, X J. Zhou, F Lin, A Fairhurst, C Boudreaux, C Roux, EK. Wakeland, L Davis, Batteux, and C Mohan. 2010. Dysregulated Expression of CXCR4/CXCL12 in Subsets of Patients with Systemic Lupus Erythematosus. Arthritis Rheum 62: 3436–3446

Santiago-Raber ML. Dunand-Sauthier I. Wu T. Li QZ. Uematsu S. Akira S. Reith W. Mohan C. Kotzin BL. Izui S. Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice.. J Autoimmunity. 34(4):339-48, 2010

Jiankun Zhu, Chandra Mohan. Toll-like Receptor Signaling Pathway – Therapeutic Opportunities. Mediators of Inflammation. 2010:781235, 2010

2009

Wu T and C. Mohan. 2009. Proteomic toolbox for autoimmunity research. Autoimmunity Reviews 8(7):595-8

Hasna Kanta and Chandra Mohan. 2009. Murine Lupus genes target 3 checkpoints in disease development-central tolerance in the adaptive immune system, peripheral amplification by innate immunity, and end-organ inflammation. Genes Immunity 10(5):390-6

Chaim O Jacob, Jiankun Zhu, et al., and Mohan C. 2009. Identification of IRAK1 as a disease gene in systemic lupus erythematosus through combined forward genetic and reverse genetic approaches. Proc Natl Acad Sci USA 106(15):6256-61

Kui Liu and Chandra Mohan. 2009. Altered B Cell Signaling in Lupus. Autoimmunity Rev 8:214-218

Zhiyan Liang, Sooghee Chang, Min So Youn, and Chandra Mohan. 2009. Molecular Hallmarks of Anti-chromatin Antibodies Associated with the Lupus Susceptibility Locus, Sle1. Mol Immunol 46(13):2671-81

Chang S. Yang L. Moon YM. Cho YG. Min SY. Kim TJ. Kim YJ. Patrick W. Kim HY. Mohan C. 2009. Anti-nuclear antibody reactivity in lupus may be partly hard-wired into the primary B-cell repertoire. Mol Immunol. 46(16):3420-6.

Vuyyuru R. Mohan C. Manser T. Rahman ZS. 2009. The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints. J Immunol 183(9):5716-27

Kui Liu, Quan-Zhen Li, Anna-Karin Abelson, Elena Sánchez, Jennifer A. Kelly, et al, and Mohan C. 2009. Kallikreins as disease genes in lupus and anti-glomerular antibody-induced nephritis. J Clin Invest 119(4): 911-923

Quan-Zhen Li, Jinchun Zhou, Ru Yang, Mei Yan, Qiu Ye, Kui Liu, Nancy Liu, Xinli Shao, Li Li, Ward Wakeland, and Chandra Mohan. 2009. The lupus susceptibility gene kallikrein down-modulates antibody-mediated glomerulonephritis. Genes Immunity 10(5):503-8.

Anna-Marie Fairhurst, Chun Xie, Yuyang Fu, Andrew Wang Christopher Boudreaux, Xin J Zhou, Ricardo Cibotti, Anthony Coyle, John E Connolly, Edward K. Wakeland, Chandra Mohan. 2009. Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis. J Immunol (183(10):6831-8

Andrew Wang, Anna-Marie Fairhurst, Katalin Tus, Srividya Subramanian, Yang Liu, Fangming Lin, Peter Igarashi1, Xin J. Zhou, Frederic Batteux, Donald Wong, Edward K.Wakeland, and Chandra Mohan. 2009. CXCR4/CXCL12 hyperexpression plays a pivotal role in lupus pathogenesis. J Immunol 182:4448-4458.

T Wu and Mohan C. 2009. The AKT axis as a therapeutic target in autoimmune diseases. Endocrine, Metabolic & ImmuneDisorders – Drug Targets. 9(2):145-50.

Chong BF. Mohan C. 2009. Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus. Expert Opinion on Therapeutic Targets. 13(10):1147-53

2008

Y Du, Y Fu and C Mohan. 2008. Experimental anti-GBM nephritis as an analytical tool for studying spontaneous lupus nephritis. Archivum Immunologiae et Therapiae Experimentalis. 56:1-10

Kumar KR. Mohan C. Understanding B-cell tolerance through the use of immunoglobulin transgenic models. Immunol Res. 40(3):208-23, 2008.

Y Liu, L Li and C Mohan. 2008. The role of rearrangement at the second immunoglobulin heavy chain locus in maintaining B-cell tolerance to DNA J Immunol 180(11):7721-7

C Xie, ZSM Rahman, S Xie, J Zhu, Y Du, X Qin, H Zhou, XJ Zhou, and C Mohan. 2008. Strain distribution pattern of immune nephritis – a follow-up study. International Immunol 20(6):719-728

Jack Hutcheson, John C. Scatizzi, Akbar M. Siddiqui, G. Kenneth Haines, Tianfu Wu, Quan-Zhen Li, Laurie S. Davis, Chandra Mohan, and Harris Perlman. Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity. Immunity 2008 28: 206-217

2007

Li QZ. Zhou J. Wandstrat AE. Carr-Johnson F. Branch V. Karp DR. Mohan C. Wakeland EK. Olsen NJ. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol. 147(1):60-70, 2007

Wu T. Mohan C. Proteomics on the diagnostic horizon: Lessons from rheumatology. Am J Med Sci. 333(1):16-25, 2007

Chun Xie, Rahul Patel, Tianfu Wu, Jiankun Zhu, Tamika Henry, Madhavi Bhaskarabhatla, Renuka Samudrala, Katalin Tus, Yimei Gong, Hui Zhou, Edward K. Wakeland, Xin J. Zhou, and Chandra Mohan. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr . International Immunol. 2007; 19: 509-522

Xie C, Qin X, Jonnala G, Zhou XJ, and Mohan C. 2007. Enhanced immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol 124(1):49-56

Zhu J. Mohan C. SLE 1, 2, 3…genetic dissection of lupus. Adv Exp Med Biol. 601:85-95, 2007

Li L. Mohan C. Genetic basis of murine lupus nephritis. Seminars in Nephrology. 27(1):12-21, 2007

Liu K. Li QZ. Yu Y. Liang C. Subramanian S. Zeng Z. Wang HW. Xie C. Zhou XJ. Mohan C. Wakeland EK. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes & Immunity. 8(8):634-45, 2007

Liu Y, L Li, C Xie, S Lightfoot, X J. Zhou, M Weigert and C Mohan. 2007. Lupus susceptibility loci breach B-cell tolerance to DNA by impairing receptor revision of nuclear antigen reactive B-cells. J Immunol 179: 1340 – 1352

Xiaoyan Shi, Chun Xie, Sooghee Chang, Xin J Zhou, Thomas Tedder and Chandra Mohan. 2007. CD19 hyper-expression augments Sle1-induced humoral autoimmunity but not clinical nephritis. Arthritis Rheum 56(9):3057-69

KR Kumar and C. Mohan. 2007. B-cell tolerance checkpoint violations in systemic lupus erythematosus. Future Rheumatology 2(4): 415-422.

Culton DA, Nicholas MW, Bunch DO, et al.. Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss. J Clin Immunol 27 (1): 53-68, 2007

T Wu, X Qin, Liu K, Z Kurepa, M Bhaskarabhatla, XJ Zhou, Satterthwaite AB, LS Davis and C Mohan. 2007. Shared signaling networks that fire up in lupus B cells from genetically distinct mouse models – implications for disease pathogenesis and therapy. J Clin Invest 117: 2186 – 2196

Xie C, Qin X, Jonnala G, Zhou XJ, and Mohan C. 2007. Enhanced immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol 124(1):49-56

Fu Y, Yong D and Mohan C. 2007. The experimental anti-GBM model as a tool for studying spontaneous lupus nephritis. Clin Immunol 124: 109-118

Xie C, Qin X, Xie S, Zhu J, Zhou XJ, and Mohan C. 2007. Strain distribution pattern of mice to anti-GBM nephritis – a follow up study. International Immunol (Acceptance pending revision).

T Wu, C Xie, HW Wang, XJ Zhou, N Schwartz, M Mackay, C Aranow, C Putterman, and C Mohan. 2007. Elevated urinary VCAM-1, P-selectin, sTNFR-1 and CXCL16 in multiple murine lupus strains and human lupus nephritis. J Immunol 179(10):7166-75

Li L. Mohan C. Genetic basis of murine lupus nephritis. Seminars in Nephrology. 27(1):12-21, 2007

Wu T. Xie C. Bhaskarabhatla M. Yan M. Leone A. Chen SS. Zhou XJ. Putterman C. Mohan C. Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance. Arthritis Rheum. 56(3):949-59, 2007

Wu TF, Mohan C. Three pathogenic determinants in immune nephritis – anti-glomerular antibody specificity, innate triggers and host genetics. Frontiers in Bioscience 12: 2207-2211, 2007

2006

Mohan C. 2006. Environment versus genetics in autoimmunity: a geneticist’s perspective. Lupus 15 (11): 791-793

Mehrad B, Park, SJ, Standiford, TJ, Zhu, J, Wu T, and Mohan C. 2006. Lupus susceptibility loci promote anti-bacterial host defenses. J Immunol 176: 3233 – 3239.

Mohan DP and Mohan C. 2006. Genetics of autoimmunity in man and mice. Book Chapter in Genes, Genomes and Genomics. Regency Publications.

Kumar KR, L Li, M Yan, M Bhaskarabhatla, AB Mobley, C Nguyen, J Mooney, JD Schatzle, EK Wakeland and C Mohan . 2006. Regulation of B-cell tolerance by the lupus susceptibility gene Ly108. Science 2006, 312(5780):1665

Wang A and Mohan C. 2006. Identification of the Yaa lupus gene as a Tlr7 gene duplication event. Future Rheum 1(5):563-565

Qing X. Zavadil J. Crosby MB. Hogarth MP. Hahn BH. Mohan C. Gilkeson GS. Bottinger EP. Putterman C. Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells. Arthritis Rheum 54(7):2198-210, 2006

Y Fu, C Xie, J Zhu, J Thomas, XJ Zhou, and C Mohan. 2006. Innate immune nephritis – A novel experimentally induced murine nephritis model contingent upon FcR and Toll receptor stimulation and IL-1/TNF-a production. J Immunol 176: 632 – 639

Liu K. Mohan C. What do mouse models teach us about human SLE?. Clin Immunol. 119(2):123-30, 2006

2005

Zhen QL. Xie C. Wu T. Mackay M. Aranow C. Putterman C. Mohan C. 2005. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest 115:3428-3439

Henry T, and Mohan C. 2005. Lesson in lupus from congenic strains. Archivum Immunologiae et Therapiae Experimentalis. 53:207-212.

Xie S., Sharma R., Kaliyaperumal A., Datta SK., and C. Mohan. 2005. Genetics of lupus susceptibility in NZB/SWR hybrids – lessons from an intercross study. Arthritis Rheum 52(2):659-667.

Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, and Mohan C. 2005. Genetic dissection of lupus: T-cell hyperactivity as a consequence of hyperstimulatory antigen presenting cells. J Clin Invest 115(7):1869-1878

Li J, Liu Y, Xie C, Zhu J, Zhou XJ, C Mohan. 2005. Deficiency of Type I interferon contributes to Sle2-associated component lupus phenotypes. Arthritis Rheum 52:3063-3072

Chang S. and Mohan C. 2005. Identification of novel VH1/J558 immunoglobulin germline genes of C57BL/6 (Igh(b)) allotype. Molecular Immunol. 42(11):1293-1301.

Kumar K. R, Zhu J, Bhaskarabhatla M, Yan M, Mohan C. 2005. Enhanced expression of Ly-6A/E correlates with disease severity in various lupus prone mice. J Autoimmunity 25:215-222

Fu Y, Xie C, Yan M, Li Q, Lu C, and C Mohan. 2005. LPS-induced mesangial transcriptome – evaluating the role of interferon regulatory factor-1. Kidney Int 67:1350-1361

Patel R and Mohan C. PI3K/AKT signaling and systemic autoimmunity. 2005. Immunol Res 31(1):47-55.

2004

Limaye N, and Mohan C. 2004. Pathogenicity of anti-DNA and anti-glomerular antibodies: weighing the evidence. Drug Discovery Today: Disease Models 1(4):395-403.

Liang Z, Xie C, Chen C, Kreska D, Hsu K, Li L, Zhou X-J, and Mohan C. 2004. Pathogenic profiles and molecular signatures of ANAs derived from NZM2410 lupus mice. J Exp Med 199: 381-398

Limaye N, and Mohan C. 2004. Pathogenicity of anti-DNA and anti-glomerular antibodies: weighing the evidence. Drug Discovery Today: Disease Models 1(4):395-403.

Xie C, Ruchi Sharma R, Wang H, Zhou XJ, and C Mohan. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172: 5047 – 5055

2003

Raman K, and Mohan C. 2003. Genetic underpinnings of autoimmunity – lessons from studies in arthritis, diabetes, lupus and multiple sclerosis. Curr Opin Immunol 15(6):651-659.

Xie S, and C Mohan. 2003. Divide and conquer – the power of congenic strains. Clin Immunol. YCLIM-05443

Sedrak P, Hsu K, Mohan C. 2003. Molecular signatures of anti-nuclear antibodies – contribution of heavy chain framework residues. Mol Immunol 40:483-563.

Liang Z, Chen C and Mohan C. 2003. Molecular signatures of anti-nuclear antibodies – contributions of specific light chain residues and a novel NZB Vk1 germline gene. J Immunol 171:3886-94

Xie C, Liang E, and Mohan C. (2003) Use of a novel elution regime reveals the dominance of cross-reactive anti-dsDNA autoantibodies in lupus kidneys. Arthritis Rheum 48:2343-2352.

Xie C, Zhou JX, and Mohan C. (2003) Enhanced susceptibility to nephritis in the lupus facilitating NZW strain. Arthritis Rheum 48:1080-1092

2002

Shi X, Xie C, Kreska D, Richardson J, Mohan C. (2002) Genetic Dissection of SLE: Sle1 and Fas impact distinct pathways leading to lymphoproliferative autoimmunity. J Exp Med 196:281-292

Xie S, Chang S, Sedrak P, Kaliyaperumal A, Datta SK, Mohan C. (2002). Dominant NZB contributions to lupus in the (SWR X NZB)F1 model. Genes and Immunity 3: S13-S20

Chen L, Chang, S, and Mohan C. (2002) Molecular Signatures of anti-ssDNA, anti-dsDNA, and anti-nucleosome autoantibody heavy chains. Mol Immunol 39: 333-347

Shi X, Xie C, Kreska D, Richardson J, Mohan C. (2002) Genetic Dissection of SLE: Sle1 and Fas impact distinct pathways leading to lymphoproliferative autoimmunity. J Exp Med 196:281-292

2001

Xie S-K, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta SK, Mohan, C. (2001) Genetic contributions of SWR towards lupus nephritis. J Immunol 167:7150-7156.

Mohan C. (2001). Murine Lupus Genetics: Lessons Learned. Curr Opin Rheumatol 13:352-360

Mohan C, Liu F, Xie C, Williams R. (2001) Antisubnucleosome reactivities in SLE patients and their first degree relatives. Clin Exp Immunol 123:119-126

Xie S-K, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta SK, Mohan, C. (2001) Genetic contributions of SWR towards lupus nephritis. J Immunol 167:7150-7156

2000

Mohan C. (2000). Immunogenetic Origins of Lupus. Br Int Med J 2: 1-15

Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G, Wakeland EK. (2000). Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci USA 97:6670

1999

Mohan C, Morel L, Wakeland EK. (1999). Genetic insights into murine lupus. In Lupus: Molecular and Cellular Pathogenesis. G.C. Tsokos and G. Kammer (eds.) Humana Press. pg. 124-139.

Mohan C, Morel, L, Yang, P, Watanabe, H, Croker, B, Gilkeson, G, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: A recipe for nephrophilic autoantibodies. J Clin Invest 103:1685-1695.

Mohan C, Yu Y, Morel L, Yang P, Wakeland E.K. (1999). Genetic dissection of SLE pathogenesis: Sle3 impacts T-cell activation, differentiation and cell death. J Immunol 162:6492-6502.

Morel L, Mohan C, Schiffenbauer J, Rudofsky UH, Longmate JA, Sobel ES, Tian X-H, Wakeland EK. (1999). Complex inheritance of complex phenotypes in a murine model of lupus. Mammalian Genome 10:176-181.

Sobel ES, Mohan C, Morel L, Schiffenbauer J, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 on murine chromosome 1 by bone marrow. J Immunol 162:2415-2421

Mohan C, Morel, L, Yang, P, Watanabe, H, Croker, B, Gilkeson, G, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: A recipe for nephrophilic autoantibodies. J Clin Invest 103:1685-1695

Mohan C, Yu Y, Morel L, Yang P, Wakeland E.K. (1999). Genetic dissection of SLE pathogenesis: Sle3 impacts T-cell activation, differentiation and cell death. J Immunol 162:6492-6502

1998

Mohan C, Alas E, Morel L, Yang P, Wakeland EK. (1998). Genetic dissection of SLE pathogenesis: Sle1 on murine chromosome 1 leads to selective loss of tolerance to chromatin components. J Clin Invest 101:1362-1372

Mohan C, Morel L, Yang P, Wakeland EK. (1998). Expansion of splenic B1-cells with strong antigen presenting capabilities in the NZM2410 lupus strain. Arthritis Rheum 41:1652-1662

1997

Mohan C, Morel L, Yu Y, Croker B, Tian X-H, Deng A, Wakeland, EK. (1997). Functional dissection of SLE pathogenesis using congenic mouse strains. J Immunol 158:6019-6028.

Mohan C, Morel L, Yang P, Deng A, Wakeland EK. (1997). Genetic dissection of SLE pathogenesis : Sle2 on murine chromosome 4 leads to B-cell hyperactivity. J Immunol 159:454-465

Mohan C, Morel L, Yang P, Deng A, Wakeland EK. (1997). Genetic dissection of SLE pathogenesis: Sle2 on murine chromosome 4 leads to B-cell hyperactivity. J Immunol 159:454-465

1995

Mohan C, Shi Y, Laman JD, Datta SK. (1995) Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J Immunol 154:1470-1480.

Mohan C, and Datta SK. (1995) Lupus: Key pathogenic mechanisms and contributing factors. Clin Immunol Immunopathol 77(3):209-220.

Datta SK, Mohan C, Desai-Mehta A. (1995) Mechanisms of the pathogenic autoimmune response in lupus: prospects for specific immunotherapy. Immunol Res 14:132-147

1993

Mohan C, Adams S, Stanik V, Datta SK. (1993). Nucleosomes: A major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 177:1367-1381

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