Manuscripts on Genetics

Mohan C, Morel L, Yu Y, Croker B, Tian X-H, Deng A, Wakeland, EK. (1997). Functional dissection of SLE pathogenesis using congenic mouse strains. J Immunol 158:6019-6028.

Mohan C, Morel L, Yang P, Deng A, Wakeland EK. (1997). Genetic dissection of SLE pathogenesis : Sle2 on murine chromosome 4 leads to B-cell hyperactivity. J Immunol 159:454-465.

Mohan C. (1998). SLE: pathogenic mechanisms and genetic origins. Annals Acad Med Singapore 27:29-34.

Mohan C, Alas E, Morel L, Yang P, Wakeland EK. (1998). Genetic dissection of SLE pathogenesis: Sle1 on murine chromosome 1 leads to selective loss of tolerance to chromatin components. J Clin Invest 101:1362-1372

Mohan C, Morel L, Wakeland EK. (1999). Genetic insights into murine lupus. In Lupus: Molecular and Cellular Pathogenesis. G.C. Tsokos and G. Kammer (eds.) Humana Press. pg. 124-139.

Mohan C, Morel, L, Yang, P, Watanabe, H, Croker, B, Gilkeson, G, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: A recipe for nephrophilic autoantibodies. J Clin Invest 103:1685-1695.

Mohan C, Yu Y, Morel L, Yang P, Wakeland E.K. (1999). Genetic dissection of SLE pathogenesis: Sle3 impacts T-cell activation, differentiation and cell death. J Immunol 162:6492-6502.

Morel L, Mohan C, Schiffenbauer J, Rudofsky UH, Longmate JA, Sobel ES, Tian X-H, Wakeland EK. (1999). Complex inheritance of complex phenotypes in a murine model of lupus. Mammalian Genome 10:176-181.

Sobel ES, Mohan C, Morel L, Schiffenbauer J, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 on murine chromosome 1 by bone marrow. J Immunol 162:2415-2421

Mohan C. (2000). Immunogenetic Origins of Lupus. Br Int Med J 2: 1-15

Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G, Wakeland EK. (2000). Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci USA 97:6670

Xie S-K, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta SK, Mohan, C. (2001) Genetic contributions of SWR towards lupus nephritis. J Immunol 167:7150-7156.

Mohan C. (2001). Murine Lupus Genetics: Lessons Learned. Curr Opin Rheumatol 13:352-360

Shi X, Xie C, Kreska D, Richardson J, Mohan C. (2002) Genetic Dissection of SLE: Sle1 and Fas impact distinct pathways leading to lymphoproliferative autoimmunity. J Exp Med 196:281-292

Xie S, Chang S, Sedrak P, Kaliyaperumal A, Datta SK, Mohan C. (2002). Dominant NZB contributions to lupus in the (SWR X NZB)F1 model. Genes and Immunity 3: S13-S20.

Raman K, and Mohan C. 2003. Genetic underpinnings of autoimmunity – lessons from studies in arthritis, diabetes, lupus and multiple sclerosis. Curr Opin Immunol 15(6):651-659.

Xie S, and C Mohan. 2003. Divide and conquer – the power of congenic strains. Clin Immunol. YCLIM-05443

Henry T, and Mohan C. 2005. Lesson in lupus from congenic strains. Archivum Immunologiae et Therapiae Experimentalis. 53:207-212.

Xie S., Sharma R., Kaliyaperumal A., Datta SK., and C. Mohan. 2005. Genetics of lupus susceptibility in NZB/SWR hybrids – lessons from an intercross study. Arthritis Rheum 52(2):659-667.

Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, and Mohan C. 2005. Genetic dissection of lupus: T-cell hyperactivity as a consequence of hyperstimulatory antigen presenting cells. J Clin Invest 115(7):1869-1878

Li J, Liu Y, Xie C, Zhu J, Zhou XJ, C Mohan. 2005. Deficiency of Type I interferon contributes to Sle2-associated component lupus phenotypes. Arthritis Rheum 52:3063-3072.

Mohan C. 2006. Environment versus genetics in autoimmunity: a geneticist’s perspective. Lupus 15 (11): 791-793

Mehrad B, Park, SJ, Standiford, TJ, Zhu, J, Wu T, and Mohan C. 2006. Lupus susceptibility loci promote anti-bacterial host defenses. J Immunol 176: 3233 – 3239.

Mohan DP and Mohan C. 2006. Genetics of autoimmunity in man and mice. Book Chapter in Genes, Genomes and Genomics. Regency Publications.

Kumar KR, L Li, M Yan, M Bhaskarabhatla, AB Mobley, C Nguyen, J Mooney, JD Schatzle, EK Wakeland and C Mohan . 2006. Regulation of B-cell tolerance by the lupus susceptibility gene Ly108. Science 2006, 312(5780):1665

Wang A and Mohan C. 2006. Identification of the Yaa lupus gene as a Tlr7 gene duplication event. Future Rheum 1(5):563-565.

Chun Xie, Rahul Patel, Tianfu Wu, Jiankun Zhu, Tamika Henry, Madhavi Bhaskarabhatla, Renuka Samudrala, Katalin Tus, Yimei Gong, Hui Zhou, Edward K. Wakeland, Xin J. Zhou, and Chandra Mohan. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr . International Immunol. 2007; 19: 509-522.

Xie C, Qin X, Jonnala G, Zhou XJ, and Mohan C. 2007. Enhanced immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol 124(1):49-56

Zhu J. Mohan C. SLE 1, 2, 3…genetic dissection of lupus. Adv Exp Med Biol. 601:85-95, 2007

Li L. Mohan C. Genetic basis of murine lupus nephritis. Seminars in Nephrology. 27(1):12-21, 2007

Liu K. Li QZ. Yu Y. Liang C. Subramanian S. Zeng Z. Wang HW. Xie C. Zhou XJ. Mohan C. Wakeland EK. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes & Immunity. 8(8):634-45, 2007

Y Du, Y Fu and C Mohan.  2008. Experimental anti-GBM nephritis as an analytical tool for studying spontaneous lupus nephritis. Archivum Immunologiae et Therapiae Experimentalis. 56:1-10.

Liu K. Li QZ. Yu Y. Liang C. Subramanian S. Zeng Z. Wang HW. Xie C. Zhou XJ. Mohan C. Wakeland EK. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes & Immunity. 8(8):634-45, 2007

Hasna Kanta and Chandra Mohan. 2009. Murine Lupus genes target 3 checkpoints in disease development-central tolerance in the adaptive immune system, peripheral amplification by innate immunity, and end-organ inflammation. Genes Immunity 10(5):390-6.

Chaim O Jacob, Jiankun Zhu, et al., and Mohan C. 2009. Identification of IRAK1 as a disease gene in systemic lupus erythematosus through combined forward genetic and reverse genetic approaches. Proc Natl Acad Sci USA 106(15):6256-61.

A.B. Satterthwaite & C Mohan. Genetics: Rare genes for autoimmunity—the new kids on the block. Nature Reviews Rheumatology 6, 678-679; 2010

Minghua Wu,   Chandra Mohan. B cells in Systemic Sclerosis: Emerging evidence from genetics to phenotypes. Curr Opin Rheumatology 2015 (In Press)

Mohan C, Putterman C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol. 2015 Mar 31. doi: 10.1038/nrneph.2015.33. [Epub ahead of print] Review.PMID: 25825084